Evidence map›Paper›PMID 31654724›Full record

ArticleResuscitation2019

Organ donation after resuscitation from cardiac arrest.

Jonathan Elmer, Bradley J Molyneaux, Kurt Shutterly, Susan A Stuart, Clifton W Callaway, Joseph M Darby, Amy R Weisgerber

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Resuscitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07002294 (The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07002294 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)

TypeinterventionalSponsorUniversity of PittsburghRan2026 to 2032Enrolled1,618ConditionsCardiac Arrest (CA), Heart Arrest, Heart Arrest, Out-Of-HospitalArmsTransfer to specialty care, Usual care
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. How does damage control strategy influence organ's suitability for donation after major trauma? A multi-institutional study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  6. Observational
  7. Article
  8. Article
  9. Ten Steps Toward Improving In-Hospital Cardiac Arrest Quality of Care and Outcomes.Circulation. Cardiovascular quality and outcomes · 2023
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jonathan ElmerDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: elmerjp@upmc.edu.
Bradley J MolyneauxDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kurt ShutterlyCenter for Organ Recovery and Education, Pittsburgh, PA, USA.
Susan A StuartCenter for Organ Recovery and Education, Pittsburgh, PA, USA.
Clifton W CallawayDepartment of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Joseph M DarbyDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Amy R WeisgerberCenter for Organ Recovery and Education, Pittsburgh, PA, USA.
University of Pittsburgh · USOrgan Recovery Systems (United States) · US

Funding

Quantitative electroencephalography after cardiac arrestK23NS097629 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ELMER, JONATHAN · 2017 to 2021
$945k
NINDS NIH HHS K23 NS097629
6 · The paper itself

Abstract

backgroundWe compared the characteristics and outcomes of post-arrest donors to those of other donors, described the proportion of post-arrest decedents who donated, and compared their characteristics to post-arrest decedents who did not donate.

methodsWe performed a retrospective cohort study including patients who died at a single academic medical center from January 1, 2010 to February 28, 2019. We linked our registry of consecutive post-arrest patients to donation-related data from the Center for Organ Procurement and Recovery (CORE). We used data from CORE to identify donor eligibility, first person designation, family approaches to seek consent for donation, and approach outcomes. We determined number of organs procured and number transplanted, stratified by donor type (brain death donors (BDD) vs donors after circulatory determination of death (DCD)).

resultsThere were 12,130 decedents; 1525 (13%) were resuscitated from cardiac arrest. CORE staff approached families of 836 (260 (31%) post-arrest, 576 (69%) not post-arrest) to request donation. Post-arrest patients and families were more likely to authorize donation (172/260 (66%) vs 331/576 (57%), P = 0.02), and more likely to be DCDs (50/146 (34%) vs 55/289 (19%), P < 0.001). Overall, 4.1 ± 1.5 organs were procured and 2.9 ± 1.9 transplanted per BDD, which did not differ by post-arrest status, 3.2 ± 1.2 organs were procured and 1.8 ± 1.1 transplanted per DCD. Number of organs transplanted per DCD did not differ by post-arrest status. Unfavorable arrest characteristics were more common among post-arrest organ donors compared to non-donors.

conclusionPatients resuscitated from cardiac arrest with irrecoverable brain injury have excellent potential to become organ donors.

Indexed as

AdultAgedBrain DeathCardiopulmonary ResuscitationFamilyFemaleHeart ArrestHumansMaleMiddle AgedRetrospective StudiesTissue and Organ ProcurementTissue DonorsBrain deathCardiac arrestOrgan donationResuscitation

Identifiers

PMID31654724
PMCPMC6888847
OpenAlexW2981750792

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.