Evidence map›Paper›PMID 31654681›Full record

ReviewFrontiers in neuroendocrinology2020

Inflammation and the dimensions of depression: A review.

Marzieh Majd, Erika F H Saunders, Christopher G Engeland

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Exploratory Cohort Study of Depressive Symptoms in South Africans with HIV-1 Subtype C: Associations with Kynurenine Pathway Metabolites and Inflammatory Markers.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  15. Article
  16. Review
  17. Gender Differences and Comorbidities in Major Depression.Advances in experimental medicine and biology · 2026
    Review
  18. Article
  19. Article
  20. Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marzieh MajdDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA. Electronic address: mum366@psu.edu.
Erika F H SaundersDepartment of Psychiatry, Pennsylvania State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA. Electronic address: esaunders@hmc.psu.edu.
Christopher G EngelandDepartment of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA; Center for Healthy Aging, The Pennsylvania State University, University Park, PA, USA; College of Nursing, The Pennsylvania State University, University Park, PA, USA. Electronic address: cge2@psu.edu.

Funding

Inflammatory Mediators of Stress and Cognitive AgingR01AG042595 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI ENGELAND, CHRISTOPHER G, GRAHAM-ENGELAND, JENNIFER ELISE · 2012 to 2016
$1.6M
NIA NIH HHS R01 AG042595
6 · The paper itself

Abstract

Patients with depressive disorders show a wide range of clinical manifestations including cognitive and neurovegetative symptoms. Importantly, these symptoms can differ in terms of biological etiology, and deconstructing depression into specific symptoms may provide valuable insight into the underlying neurobiology. Little research has examined inflammation in the context of depressive dimensions. Here we conduct a narrative review of the existing literature (21 studies) to elucidate whether the depression-inflammation link is symptom specific. Overall, there is evidence that an association exists between neurovegetative symptoms of depression and inflammation, independent of cognitive symptoms. The same cannot be said of cognitive symptoms and inflammation. There is also some evidence of gender differences in the directionality of the relationship between depression and inflammation. Potential explanations for these findings, limitations of the existing literature and recommendations for future research design are discussed.

Indexed as

AdolescentAdultAffectAgedAppetiteBiomarkersCognitionC-Reactive ProteinCytokinesDepressionFatigueFemaleHumansInflammationMaleMiddle AgedBiomarkersC-Reactive ProteinCytokinesAnhedoniaCognitive symptomC-reactive proteinCytokineDepressive symptomFatigueMoodNeurovegetative symptomSomatic symptom

Identifiers

PMID31654681
PMCPMC13105217

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.