SynthesisCurrent topics in medicinal chemistry2019
Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens.
Synthesis in Current topics in medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Characterization of Hydrogel Beads for the Gradual Release ofMicroorganisms · 2025Article
- Biochanin A Inhibits the Growth and Biofilm ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Identification and characterization of a novel decalin derivative with anti-Candida activity from Streptomyces chrestomyceticus strain ADP4.Archives of microbiology · 2024Article
- Ethyl Isothiocyanate as a Novel Antifungal Agent Against Candida albicans.Current microbiology · 2023Article
- Biofilm Formation in Medically ImportantJournal of fungi (Basel, Switzerland) · 2023Review
- Evaluation of the Antifungal Effect ofMedicina (Kaunas, Lithuania) · 2023Article
- Phenyl Pentyl Ketone and m-isobutyl Methoxy Benzoate Produced byIndian journal of microbiology · 2023Article
- Biofilm: The invisible culprit in catheter-induced candidemia.AIMS microbiology · 2023Review
- Flavonoid-Rich Fractions ofPlants (Basel, Switzerland) · 2022Article
- Bioprospecting the Antibiofilm and Antimicrobial Activity of Soil and Insect Gut Bacteria.Molecules (Basel, Switzerland) · 2022Article
- Editorial:Frontiers in microbiology · 2022Article
- Natural Kinase Inhibitors for the Treatment and Management of Endometrial/Uterine Cancer: Preclinical to Clinical Studies.Frontiers in pharmacology · 2022Review
- Editorial: Exploration of Natural Product Leads for Multitarget-Based Treatment of Cancer-Computational to Experimental Journey.Frontiers in pharmacology · 2022Article
- Antifungal Mechanisms of a Chinese Herbal Medicine, Cao Huang Gui Xiang, AgainstFrontiers in pharmacology · 2022Article
- Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp.BMC complementary medicine and therapies · 2021Article
- Anti-leishmanial compounds from microbial metabolites: a promising source.Applied microbiology and biotechnology · 2021Review
- Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi-Latest Findings.Antibiotics (Basel, Switzerland) · 2021Review
- Current and promising pharmacotherapeutic options for candidiasis.Expert opinion on pharmacotherapy · 2021Article
- Translational Informatics for Natural Products as Antidepressant Agents.Frontiers in cell and developmental biology · 2021Review
- Anti-Fungal Efficacy and Mechanisms of Flavonoids.Antibiotics (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiofilm is a critical virulence factor associated with the strains of Candida spp. pathogens as it confers significant resistance to the pathogen against antifungal drugs.
methodsA systematic review of the literature was undertaken by focusing on natural products, which have been reported to inhibit biofilms produced by Candida spp. The databases explored were from PubMed and Google Scholar. The abstracts and full text of the manuscripts from the literature were analyzed and included if found significant.
resultsMedicinal plants from the order Lamiales, Apiales, Asterales, Myrtales, Sapindales, Acorales, Poales and Laurales were reported to inhibit the biofilms formed by Candida spp. From the microbiological sources, lactobacilli, Streptomyces chrestomyceticus and Streptococcus thermophilus B had shown the strong biofilm inhibition potential. Further, the diverse nature of the compounds from classes like terpenoids, phenylpropanoid, alkaloids, flavonoids, polyphenol, naphthoquinone and saponin was found to be significant in inhibiting the biofilm of Candida spp.
conclusionNatural products from both plant and microbial origins have proven themselves as a goldmine for isolating the potential biofilm inhibitors with a specific or multi-locus mechanism of action. Structural and functional characterization of the bioactive molecules from active extracts should be the next line of approach along with the thorough exploration of the mechanism of action for the already identified bioactive molecules.
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