Evidence map›Paper›PMID 31654505›Full record

ArticleObesity (Silver Spring, Md.)2019

A Brief Neuropsychological Battery for Measuring Cognitive Functions Associated with Obesity.

Iris B Hovens, Jelle R Dalenberg, Dana M Small

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Iris B HovensModern Diet and Physiology Research Center, Yale University, New Haven, Connecticut, USA.ORCID 0000-0002-3837-4740
Jelle R DalenbergModern Diet and Physiology Research Center, Yale University, New Haven, Connecticut, USA.ORCID 0000-0001-8580-5358
Dana M SmallModern Diet and Physiology Research Center, Yale University, New Haven, Connecticut, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Richard A Flavell · 1993 to 2026
$44.0M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Pathogenesis of youth onset pre-diabetes and Type 2 diabetesR01DK111038 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA · 2016 to 2025
$7.0M
Neurocognition in youth with prediabetesR01DK114169 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA, SMALL, DANA M · 2017 to 2021
$4.0M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK111038NIDDK NIH HHS R01 DK114169NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

objectiveAlthough ample evidence links obesity to cognitive dysfunction, the trajectory of cognitive change, the underlying mechanisms, and the involvement of related factors, such as metabolic disease and diet, remain unclear. To support further investigations of BMI and cognition, this study aimed to create a concise test battery to be used in future trials.

methodsTwenty neurocognitive measures were regressed on BMI in the Human Connectome Project Healthy Young Adult S1200 data release by using linear mixed models and by adjusting for major confounders. Measures were then identified by using least absolute shrinkage and selection operator regression analysis to select tests most strongly associated with BMI. To guide further test selection, the explained variance for each variable was visualized in the final model.

resultsBMI was negatively associated with seven neurocognitive measures. Variable selection yielded a model that included years of education and, in order of model weight, delay discounting, the relational task, the Penn Progressive Matrices test, the oral reading recognition test, the Variable Short Penn Line Orientation test, and the Penn Word Memory test.

conclusionsThis research resulted in an approximate 40-minute test battery for the BMI-cognition relationship in young adults that can be used in trials investigating the interrelationship between obesity and cognitive performance.

Indexed as

AdultCognitionCognition DisordersCognitive DysfunctionFemaleHumansMaleNeuropsychological TestsObesity

Identifiers

PMID31654505
PMCPMC6868337

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.