Evidence map›Paper›PMID 31654332›Full record

ArticleAdvances in therapy2019

Optimizing the Development Strategy of Combination Therapy in Respiratory Medicine: From Isolated Airways to Patients.

Luigino Calzetta, Maria Gabriella Matera, Mario Cazzola, Paola Rogliani

Open access · hybridAbstract readComment
In one paragraph

Article in Advances in therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  7. Article
  8. Drug interaction and chronic obstructive respiratory disorders.Current research in pharmacology and drug discovery · 2021
    Review
  9. Pharmacological interactions: Synergism, or not synergism, that is the question.Current research in pharmacology and drug discovery · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Luigino CalzettaUnit of Respiratory Medicine, Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy. luigino.calzetta@uniroma2.it.ORCID 0000-0003-0456-069X
Maria Gabriella MateraUnit of Pharmacology, Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Mario CazzolaUnit of Respiratory Medicine, Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Paola RoglianiUnit of Respiratory Medicine, Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
University of Rome Tor Vergata · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current recommendations for the treatment of chronic obstructive pulmonary disease (COPD) are pushing towards triple combination therapy based on the combination of an inhaled corticosteroid (ICS) associated with two bronchodilator agents. However, dual bronchodilation remains the cornerstone for the treatment of most COPD patients. Combining a long-acting β

Indexed as

Pulmonary Disease, Chronic ObstructivePulmonary MedicineAdrenergic beta-2 Receptor AgonistsBenzoxazinesBronchodilator AgentsDrug CombinationsHumansMuscarinic AntagonistsTiotropium BromideAdrenergic beta-2 Receptor AgonistsBenzoxazinesBronchodilator AgentsDrug CombinationsMuscarinic AntagonistsolodaterolTiotropium BromideAsthmaCOPDDrug developmentHuman isolated airwaysLABA/LAMA combinationRespiratorySynergyTriple therapy

Identifiers

PMID31654332
PMCPMC6860506
OpenAlexW2981447878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.