ArticleMolecular neurobiology2020
Inflammatory Responses Induced by the Rupture of Intracranial Aneurysms Are Modulated by miRNAs.
Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
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- The strategies and advances of mRNA translation booster.Asian journal of pharmaceutical sciences · 2025Review
- The role of mindfulness training supported by virtual reality in the nonpharmacological treatment of schizophrenia-research design.Annals of general psychiatry · 2025Article
- The Role of Epigenetics in Brain Aneurysm and Subarachnoid Hemorrhage: A Comprehensive Review.International journal of molecular sciences · 2024Review
- Review
- microRNAs in Subarachnoid Hemorrhage (Review of Literature).Journal of clinical medicine · 2022Review
- MicroRNAs as Biomarkers for Predicting Complications following Aneurysmal Subarachnoid Hemorrhage.International journal of molecular sciences · 2021Review
- Diagnostic and prognostic potential of circulating miRNAs for intracranial aneurysms.Neurosurgical review · 2021Review
- Deciphering the role of microRNAs in mustard gas-induced toxicity.Annals of the New York Academy of Sciences · 2021Review
- Circular RNA expression profile in human primary multiple intracranial aneurysm.Experimental and therapeutic medicine · 2021Article
- Bioinformatics analysis of common key genes and pathways of intracranial, abdominal, and thoracic aneurysms.BMC cardiovascular disorders · 2021Article
- Identification and validation of key genes mediating intracranial aneurysm rupture by weighted correlation network analysis.Annals of translational medicine · 2020Article
- Opposite regulation of piRNAs, rRNAs and miRNAs in the blood after subarachnoid hemorrhage.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Rapidly fatal encephalitis associated with atypical lymphoid proliferations of the basal ganglia subsequent to aneurysmal subarachnoid hemorrhage.Clinics and practice · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Influence of an intracranial aneurysm (IA) rupture on the expression of miRNAs and the potential significance of the resulting changes remains poorly understood. We aimed to characterize the response to the IA rupture through the analysis of miRNAs in peripheral blood cells. Expression of small RNAs was investigated using deep transcriptome sequencing in patients in the acute phase of an IA rupture (first 72 h), in the chronic phase (3-15 months), and controls. A functional analysis and the potential interactions between miRNAs and target genes were investigated. We also measured the levels of proteins that were influenced by regulated miRNAs. We found that 106 mature miRNAs and 90 miRNA precursors were differentially expressed among the groups. The regulated miRNAs were involved in a variety of pathways, and the top pathway involved cytokine-cytokine receptor interactions. The identified miRNAs targeted the inflammatory factors HMGB1 and FASLG. Changes in their expression were detected at the mRNA and protein levels. IA rupture strongly influences the transcription profiles in peripheral blood cells. The regulated miRNAs were involved in the control of immune cell homeostasis. In summary, these results may aid in the elucidation of the molecular mechanisms that orchestrate the inflammatory response to IA rupture.
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