Evidence map›Paper›PMID 31654299›Full record

ReviewCEN case reports2020

Efficacy of Secukinumab for Plaque Psoriasis in a Patient on Hemodialysis.

Daiuske Ikuma, Masahiko Oguro, Junichi Hoshino, Hiroki Mizuno, Akinari Sekine, Masahiro Kawada, Rikako Hiramatsu, Keiichi Sumida, Eiko Hasegawa, Noriko Hayami and 5 more

Abstract readCase ReportsReview
In one paragraph

Review in CEN case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Daiuske IkumaNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan. gdikuma@gmail.com.ORCID 0000-0003-4421-6404
Masahiko OguroNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Junichi HoshinoNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Hiroki MizunoNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Akinari SekineNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Masahiro KawadaNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Rikako HiramatsuNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Keiichi SumidaNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Eiko HasegawaNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Noriko HayamiNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Masayuki YamanouchiNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Tatsuya SuwabeNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Naoki SawaNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Kenmei TakaichiNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.
Yoshifumi UbaraNephrology Center, Toranomon Hospital, 2-2-2Minato-ku, ToranomonTokyo, 105-0001, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secukinumab is effective to treat plaque psoriasis. However, the safety and efficiency of secukinumab have not been clarified in patients on hemodialysis. We report a 60-year-old Japanese woman. Plaque psoriasis was diagnosed at the age of 25 years and hemodialysis was started at the age of 39 years. Her skin lesions persisted despite use of topical agents such as maxacalcitol and betamethasone. Accordingly, administration of secukinumab was started at a dose of 150 mg. The psoriasis area and severity index (PASI) score decreased from 49.8 to 14.8 after 2 weeks and to 0 after 6 weeks, with remission being maintained after 28 months. No adverse reactions were seen. This case indicates that secukinumab may be effective for severe psoriasis in patients on hemodialysis for end-stage renal disease.

Indexed as

AgedAntibodies, Monoclonal, HumanizedAsian PeopleFemaleHumansKidney Failure, ChronicMaleMiddle AgedPsoriasisRenal DialysisSeverity of Illness IndexTreatment OutcomeAntibodies, Monoclonal, HumanizedsecukinumabHemodialysis and end stage renal disease (ESRD)Plaque psoriasisSecukinumab

Identifiers

PMID31654299
PMCPMC6990267

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.