Evidence map›Paper›PMID 31654281›Full record

SynthesisTranslational stroke research2020

From the Lab to Patients: a Systematic Review and Meta-Analysis of Mesenchymal Stem Cell Therapy for Stroke.

Manoj M Lalu, Joshua Montroy, Dar Dowlatshahi, Brian Hutton, Pascale Juneau, Neil Wesch, Sarah Y Zhang, Ryan McGinn, Dale Corbett, Duncan J Stewart and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Translational stroke research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Brain repair mechanisms after cell therapy for stroke.Brain : a journal of neurology · 2024
    Review
  11. Article
  12. Review
  13. NCAM mimetic peptide P2 synergizes with bone marrow mesenchymal stem cells in promoting functional recovery after stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Stem Cell- and Cell-Based Therapies for Ischemic Stroke.Bioengineering (Basel, Switzerland) · 2022
    Review
  20. Intranasal Salvinorin A Improves Long-term Neurological Function via Immunomodulation in a Mouse Ischemic Stroke Model.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Manoj M LaluDepartment of Anesthesiology and Pain Medicine, The Ottawa Hospital Research Institute, Room B307, 1053 Carling Ave, Mail Stop 249, Ottawa, ON, K1Y 4E9, Canada. mlalu@toh.ca.ORCID 0000-0002-0322-382X
Joshua MontroyClinical Epidemiology Program, Blueprint Translational Group, The Ottawa Hospital Research Institute, Ottawa, Canada.
Dar DowlatshahiClinical Epidemiology Program, Blueprint Translational Group, The Ottawa Hospital Research Institute, Ottawa, Canada.
Brian HuttonKnowledge Synthesis Group, Ottawa Hospital Research Institute, Ottawa, Canada.
Pascale JuneauClinical Epidemiology Program, Blueprint Translational Group, The Ottawa Hospital Research Institute, Ottawa, Canada.
Neil WeschClinical Epidemiology Program, Blueprint Translational Group, The Ottawa Hospital Research Institute, Ottawa, Canada.
Sarah Y ZhangFaculty of Medicine, University of Ottawa, Ottawa, Canada.
Ryan McGinnDepartment of Anesthesiology and Pain Medicine, The Ottawa Hospital Research Institute, Room B307, 1053 Carling Ave, Mail Stop 249, Ottawa, ON, K1Y 4E9, Canada.
Dale CorbettDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
Duncan J StewartDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
Dean A FergussonClinical Epidemiology Program, Blueprint Translational Group, The Ottawa Hospital Research Institute, Ottawa, Canada.
University of Ottawa · CAOttawa Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There may be the potential to improve stroke recovery with mesenchymal stem cells (MSCs); however, questions about the efficacy and safety of this treatment remain. To address these issues and inform future studies, we performed a preclinical and clinical systematic review of MSC therapy for subacute and chronic ischemic stroke. MEDLINE, Embase, the Cochrane Register of Controlled Trials, and PubMed were searched. For the clinical review, interventional and observational studies of MSC therapy in ischemic stroke patients were included. For the preclinical review, interventional studies of MSC therapy using in vivo animal models of subacute or chronic stroke were included. Measures of safety and efficacy were assessed. Eleven clinical and 76 preclinical studies were included. Preclinically, MSC therapy was associated with significant benefits for multiple measures of motor and neurological function. Clinically, MSC therapy appeared to be safe, with no increase in adverse events reported (with the exception of self-limited fever immediately following injection). However, the efficacy of treatment was less apparent, with significant heterogeneity in both study design and effect size being observed. Additionally, in the only randomized phase II study to date, efficacy of MSC therapy was not observed. Preclinically, MSC therapy demonstrated considerable efficacy. Although MSC therapy demonstrated safety in the clinical setting, efficacy has yet to be determined. Future studies will need to address the discordance in the continuity of evidence as MSC therapy has been translated from "bench-to-bedside".

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsBrain IschemiaHumansIschemic StrokeRisk FactorsTranslational Research, BiomedicalTreatment OutcomeClinicalIschemic strokePreclinicalStem cellsStrokeSystematic review

Identifiers

PMID31654281
OpenAlexW2981504580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.