ArticleNaunyn-Schmiedeberg's archives of pharmacology2020
Glycosylation of proteins of human skin fibroblasts is changed by rosmarinic acid.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Eriodictyol suppresses the malignant progression of colorectal cancer by downregulating tissue specific transplantation antigen P35B (TSTA3) expression to restrain fucosylation.Bioengineered · 2022Article
- Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats.Scientific reports · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycosylation is a common post-translational process of protein modification. Glycans participate in many crucial biological functions like cell differentiation, cell adhesion, cell-cell interactions, and regulation of signaling pathways. Rosmarinic acid (RA) is a natural flavonoid with many pharmacological activities including anti-inflammatory, anti-oxidative, anti-bacterial, or anti-fibrotic. In this study, we aimed to determine the effect of 25, 50, and 100 μM rosmarinic acid on specific carbohydrate antigens in human skin fibroblasts. ELISA-liked test with biotinylated lectins was used to assess the level of sugar structures in cell lysates and culture supernatant. RT-PCR was applied to determine mRNA of selected glycosyltransferases responsible for formation of sugar antigens. Rosmarinic acid inhibited the expression of Tn, T antigens and their sialylated forms, fucosylated antigens, di NAclactosamine, and mannose antigens. All used doses of RA significantly decreased core 1 β1-3galactosyltransferase mRNA and 25 and 50 μM acid significantly inhibited GalNAcα2-6-sialyltransferase mRNA. The results indicate that rosmarinic acid, due to decreasing effect on specific sugar antigens, can change some of crucial carbohydrate functions in skin fibroblasts, e.g., involved in cell adhesion and cell-cell interactions.
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