ArticleCell death and differentiation2020
Autologous micrograft accelerates endogenous wound healing response through ERK-induced cell migration.
Article in Cell death and differentiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- First-in-human clinical trial of allogeneic, platelet-derived extracellular vesicles as a potential therapeutic for delayed wound healing.Journal of extracellular vesicles · 2023Trial
- Enhancing validation of case-control omics signatures through "minimalist" single-subject analysis (N-of-1 trials): proof of concept in sepsis.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Bioactive derivatives of the antimicrobial peptide esculentin-1a promote human dermal fibroblast migration and activate genes involved in early wound healing.BBA advances · 2026Article
- Applications of Adipose Tissue Micrografts (ATM) and Dermis Micrografts (DMG) in Wound Healing: A Scoping Review of Clinical Studies.Bioengineering (Basel, Switzerland) · 2025Review
- Exosomes derived from minor salivary gland mesenchymal stem cells: a promising novel exosome exhibiting pro-angiogenic and wound healing effects similar to those of adipose-derived stem cell exosomes.Stem cell research & therapy · 2024Article
- Efficacy of Autologous Micrografting Technology in Managing Osteoarthritis Pain: A Pilot Study.Bioengineering (Basel, Switzerland) · 2024Article
- From Time to Timer in Wound Healing Through the Regeneration.Advances in experimental medicine and biology · 2024Review
- Efficacy of autologous micrografts technology: a promising approach for chronic wound healing and tissue regeneration-a pilot study.Frontiers in medicine · 2024Article
- FastSkinJournal of clinical medicine · 2023Article
- Biomaterials derived from hard palate mucosa for tissue engineering and regenerative medicine.Materials today. Bio · 2023Review
- Insights into cellular behavior and micromolecular communication in urothelial micrografts.Scientific reports · 2023Article
- Article
- Sprayed PAA-CaORegenerative biomaterials · 2023Article
- Expansion of fibroblast cell sheets using a modified MEEK micrografting technique for wound healing applications.Scientific reports · 2022Article
- Mechanistic Wound Healing and Antioxidant Potential ofAntioxidants (Basel, Switzerland) · 2022Article
- A Histological Evaluation of Artificial Dermal Scaffold Used in Micrograft Treatment: A Case Study of Micrograft and NPWT Performed on a Postoperative Ulcer Formation after Tumor Resection.Medicina (Kaunas, Lithuania) · 2022Article
- Autologous Bioactive Compound Concentrated Growth Factor Ameliorates Fistula Healing of Anal Fistula in a Pig Model and Promotes Proliferation and Migration of Human Skin Fibroblasts via Regulating the MEK/ERK Pathway.Oxidative medicine and cellular longevity · 2022Article
- 3D bioprinting and RigeneraFrontiers in bioengineering and biotechnology · 2022Article
- 'Single-subject studies'-derived analyses unveil altered biomechanisms between very small cohorts: implications for rare diseases.Bioinformatics (Oxford, England) · 2021Article
- Upregulation of miR181a/miR212 Improves Myogenic Commitment in Murine Fusion-Negative Rhabdomyosarcoma.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defective cell migration causes delayed wound healing (WH) and chronic skin lesions. Autologous micrograft (AMG) therapies have recently emerged as a new effective and affordable treatment able to improve wound healing capacity. However, the precise molecular mechanism through which AMG exhibits its beneficial effects remains unrevealed. Herein we show that AMG improves skin re-epithelialization by accelerating the migration of fibroblasts and keratinocytes. More specifically, AMG-treated wounds showed improvement of indispensable events associated with successful wound healing such as granulation tissue formation, organized collagen content, and newly formed blood vessels. We demonstrate that AMG is enriched with a pool of WH-associated growth factors that may provide the starting signal for a faster endogenous wound healing response. This work links the increased cell migration rate to the activation of the extracellular signal-regulated kinase (ERK) signaling pathway, which is followed by an increase in matrix metalloproteinase expression and their extracellular enzymatic activity. Overall we reveal the AMG-mediated wound healing transcriptional signature and shed light on the AMG molecular mechanism supporting its potential to trigger a highly improved wound healing process. In this way, we present a framework for future improvements in AMG therapy for skin tissue regeneration applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.