ArticleScientific reports2019
Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Modern Cyanine Dye-Based Photosensitizers for Medical Applications.Angewandte Chemie (International ed. in English) · 2026Review
- Annulated cationic tetramethyl indo(di)carbocyanine dyes exhibit potent dark cytotoxicity in cancer cells.Dyes and pigments : an international journal · 2026Article
- Counterion-Enhanced Brightness of Fluorous-Soluble Heptamethine Cyanine Dyes for Near- and Shortwave Infrared Fluorescence Imaging.Chemical & biomedical imaging · 2026Article
- Chemically inducible antisense oligonucleotides for cell-specific gene silencing.RSC chemical biology · 2025Article
- Cancer in translation: cyanine carborane salts: a multifunctional theranostic approach to cancer treatment.EJNMMI radiopharmacy and chemistry · 2025Article
- ICG/MnOLasers in medical science · 2025Article
- Next-Generation Photosensitizers: Cyanine-Carborane Salts for Superior Photodynamic Therapy of Metastatic Cancer.Angewandte Chemie (International ed. in English) · 2025Article
- Counterion Exchange Enhances the Brightness and Photostability of a Fluorous Cyanine Dye.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Inner-filter effect of nitrogen-doped carbon quantum dots-MnORSC advances · 2024Article
- Raman Flow Cytometry and Its Biomedical Applications.Biosensors · 2024Review
- Review
- Room-Temperature Phosphorescence and Cellular Phototoxicity Activated by Triplet Dynamics in Aggregates of Push-Pull Phenothiazine-Based Isomers.The journal of physical chemistry. B · 2023Article
- Phosphorescent Metal Halide Nanoclusters for Tunable Photodynamic Therapy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Counterion Tuning of Near-Infrared Organic Salts Dictates Phototoxicity to Inhibit Tumor Growth.ACS applied materials & interfaces · 2022Article
- An Insight into Symmetrical Cyanine Dyes as Promising Selective Antiproliferative Agents in Caco-2 Colorectal Cancer Cells.Molecules (Basel, Switzerland) · 2022Article
- Highly Photostable Carbon Dots from Citric Acid for Bioimaging.Materials (Basel, Switzerland) · 2022Article
- Polymethine dyes for PDT: recent advances and perspectives to drive future applications.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Review
- Copper-carbon hybrid nanoparticles as antimicrobial additives.MRS communications · 2022Article
- Synthesis of poly(RSC advances · 2020Article
- Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light-activated theranostics offer promising opportunities for disease diagnosis, image-guided surgery, and site-specific personalized therapy. However, current fluorescent dyes are limited by low brightness, high cytotoxicity, poor tissue penetration, and unwanted side effects. To overcome these limitations, we demonstrate a platform for optoelectronic tuning, which allows independent control of the optical properties from the electronic properties of fluorescent organic salts. This is achieved through cation-anion pairing of organic salts that can modulate the frontier molecular orbital without impacting the bandgap. Optoelectronic tuning enables decoupled control over the cytotoxicity and phototoxicity of fluorescent organic salts by selective generation of mitochondrial reactive oxygen species that control cell viability. We show that through counterion pairing, organic salt nanoparticles can be tuned to be either nontoxic for enhanced imaging, or phototoxic for improved photodynamic therapy.
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Registered trials
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