Evidence map›Paper›PMID 31653846›Full record

ArticleNature communications2019

Reverberant 3D optical coherence elastography maps the elasticity of individual corneal layers.

Fernando Zvietcovich, Pornthep Pongchalee, Panomsak Meemon, Jannick P Rolland, Kevin J Parker

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 131 citations in OpenAlex.

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  5. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
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  18. Toward quantitative X-ray elastography of coronary arteries using flexural pulse waves.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Fernando ZvietcovichDepartment of Electrical and Computer Engineering, University of Rochester, Rochester, NY, 14627-0126, USA.
Pornthep PongchaleeSuranaree University of Technology, Nakhon Ratchasima, Thailand, 30000.
Panomsak MeemonSuranaree University of Technology, Nakhon Ratchasima, Thailand, 30000.
Jannick P RollandThe Institute of Optics, University of Rochester, Rochester, NY, 14627-0186, USA.
Kevin J ParkerDepartment of Electrical and Computer Engineering, University of Rochester, Rochester, NY, 14627-0126, USA. kevin.parker@rochester.edu.
University of Rochester · USSuranaree University of Technology · TH

Funding

The H-scan approach to classifying ultrasound echoesR21EB025290 · NIBIB · UNIVERSITY OF ROCHESTER · PI PARKER, KEVIN J · 2018 to 2019
$420k
NIBIB NIH HHS R21 EB025290
6 · The paper itself

Abstract

The elasticity mapping of individual layers in the cornea using non-destructive elastography techniques advances diagnosis and monitoring of ocular diseases and treatments in ophthalmology. However, transient Lamb waves, currently used in most dynamic optical coherence and ultrasound elastography techniques, diminish the translation of wave speed into shear/Young's modulus. Here, we present reverberant 3D optical coherence elastography (Rev3D-OCE), a novel approach leveraging the physical properties of diffuse fields in detecting elasticity gradients not only in the lateral direction, but also along the depth axis of the cornea. A Monte Carlo analysis, finite element simulations, and experiments in layered phantoms are conducted to validate the technique and to characterize the axial elastography resolution. Experiments in ex vivo porcine cornea at different intraocular pressures reveal that Rev3D-OCE enables the elastic characterization of single layers that matches the anatomical description of corneal layers with unprecedented contrast in the dynamic OCE field.

Indexed as

AnimalsCorneaElasticityElasticity Imaging TechniquesFinite Element AnalysisImaging, Three-DimensionalMonte Carlo MethodPhantoms, ImagingSwineTomography, Optical Coherence

Identifiers

PMID31653846
PMCPMC6814807
OpenAlexW2981758685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.