ArticleGenetics2019
The Fate of Deleterious Variants in a Barley Genomic Prediction Population.
Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Measuring the change in deleterious mutation burden of barley germplasm conserved over one regeneration cycle.G3 (Bethesda, Md.) · 2026Article
- Prioritization of deleterious mutations informs genomic prediction and increases the rate of gain in common bean (Phaseolus vulgaris L.), a simulation study.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Genomic constraint and hypervariability correlate with fitness effects in elite tetraploid potato breeding material.PLoS genetics · 2026Article
- Accumulating Heterozygous Deleterious Mutations in Conserved Soybean Germplasm over Successive Regenerations.Plants (Basel, Switzerland) · 2025Article
- Elevated Mutation Burdens in Canadian Oat and Wheat Cultivars Released over the Past Century.Cells · 2025Article
- Evolutionary signatures of the erosion of sexual reproduction genes in domesticated cassava (Manihot esculenta).G3 (Bethesda, Md.) · 2025Article
- Biologically meaningful genome interpretation models to address data underdetermination for the leaf and seed ionome prediction in Arabidopsis thaliana.Scientific reports · 2024Article
- Patterns of the Predicted Mutation Burden in 19,778 Domesticated Barley Accessions Conserved Ex Situ.International journal of molecular sciences · 2024Article
- Deleterious and Adaptive Mutations in Plant Germplasm Conserved Ex Situ.Molecular biology and evolution · 2023Article
- Unraveling Prevalence and Effects of Deleterious Mutations in Maize Elite Lines across Decades of Modern Breeding.Molecular biology and evolution · 2023Article
- If it ain't broke, don't fix it: evaluating the effect of increased recombination on response to selection for wheat breeding.G3 (Bethesda, Md.) · 2022Article
- The evolutionary patterns of barley pericentromeric chromosome regions, as shaped by linkage disequilibrium and domestication.The Plant journal : for cell and molecular biology · 2022Article
- Deleterious Mutations and the Rare Allele Burden on Rice Gene Expression.Molecular biology and evolution · 2022Article
- Genome-wide imputation using the practical haplotype graph in the heterozygous crop cassava.G3 (Bethesda, Md.) · 2022Article
- Utilizing evolutionary conservation to detect deleterious mutations and improve genomic prediction in cassava.Frontiers in plant science · 2022Article
- Horizontally Acquired nrDNAs Persist in Low Amounts in HostFrontiers in plant science · 2021Article
- Environmental Association Identifies Candidates for Tolerance to Low Temperature and Drought.G3 (Bethesda, Md.) · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeted identification and purging of deleterious genetic variants has been proposed as a novel approach to animal and plant breeding. This strategy is motivated, in part, by the observation that demographic events and strong selection associated with cultivated species pose a "cost of domestication." This includes an increase in the proportion of genetic variants that are likely to reduce fitness. Recent advances in DNA resequencing and sequence constraint-based approaches to predict the functional impact of a mutation permit the identification of putatively deleterious SNPs (dSNPs) on a genome-wide scale. Using exome capture resequencing of 21 barley lines, we identified 3855 dSNPs among 497,754 total SNPs. We generated whole-genome resequencing data of
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