Evidence map›Paper›PMID 31653606›Full record

SynthesisBrazilian journal of otorhinolaryngology

Does topical application of tranexamic acid reduce intraoperative bleeding in sinus surgery during general anesthesia?

Haram Kang, Se Hwan Hwang

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06725732 (Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score. A Randomized Double Blinded Controlled Trial.), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06725732 early_phase1recruitingnot on this map

Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score. A Randomized Double Blinded Controlled Trial.

TypeinterventionalSponsorAssiut UniversityRan2025 to 2026Enrolled90ConditionsBlood Loss, SurgicalArmsTranexamic Acid (TXA), Tranexamic Acid
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. A Comparison of Tranexamic Acid in Nasal Versus Sinus Surgeries: a Systematic Review and Meta-Analysis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Tranexamic acid in otorhinolaryngology - A contemporary review.World journal of otorhinolaryngology - head and neck surgery · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Haram KangThe Catholic University of Korea, College of Medicine, Department of Otolaryngology-Head and Neck Surgery, Seoul, Republic of Korea.
Se Hwan HwangThe Catholic University of Korea, College of Medicine, Department of Otolaryngology-Head and Neck Surgery, Seoul, Republic of Korea. Electronic address: yellobird@catholic.ac.kr.
Catholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTranexamic acid is a hemostatic agent, which inhibits fibrin degradation, which may be beneficial in controlling bleeding during surgery.

objectivesThe purpose of this study was to provide a meta-analysis and review of the effects of tranexamic acid on hemorrhage and surgical fields and side effects on patients during endoscopic sinus surgery.

methodsTwo authors independently searched six databases (Medline, Scopus, Embase, Web of Science, Google Scholar and Cochrane library) from the start of article collection until July 2018. Postoperative complications such as intraoperative bleeding, operative time, hypotension, nausea, vomiting, and coagulation profile were included in the analysis of tranexamic acid (Treatment Group) and placebo (Control Group) during the operation.

resultsThe amount of blood loss during surgery was statistically lower in the treatment group compared to the placebo group, and the surgical field quality was statistically higher in the treatment group than in the placebo group. On the other hand, there was no significant difference in operation time, hemodynamics, or coagulation profile between groups. In addition, tranexamic acid had no significant effect on vomiting and thrombosis compared to the Control Group.

conclusionThis meta-analysis has shown that topical administration of tranexamic acid can reduce the amount of bleeding during surgery and improve the overall quality of the surgery. Hemodynamic instability during surgery, vomiting after surgery, or abnormal clotting profile were not reported. Additional studies are needed to confirm the results of this study because there are fewer studies.

Indexed as

Administration, TopicalAnesthesia, GeneralAntifibrinolytic AgentsBlood Loss, SurgicalEndoscopyEpistaxisHumansIntraoperative ComplicationsNasal Surgical ProceduresRandomized Controlled Trials as TopicTranexamic AcidAntifibrinolytic AgentsTranexamic AcidÁcido tranexâmicoCirurgia endoscópica do seio nasalEndoscopic sinus surgeryMeta-analysisMetanáliseOperative bleedingRevisão sistemáticaSangramento operatórioSystematic reviewTranexamic acid

Identifiers

PMID31653606
PMCPMC9422563
OpenAlexW2977667236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.