Evidence map›Paper›PMID 31653448›Full record

ArticleBiophysical journal2020

Simultaneous Release of Multiple Vesicles from Rods Involves Synaptic Ribbons and Syntaxin 3B.

Cassandra L Hays, Justin J Grassmeyer, Xiangyi Wen, Roger Janz, Ruth Heidelberger, Wallace B Thoreson

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Syntaxin 3B: A SNARE Protein Required for Vision.International journal of molecular sciences · 2024
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Collagen IV-β1-Integrin Influences INS-1 Cell Insulin SecretionFrontiers in cell and developmental biology · 2022
    Article
  11. Transmission at rod and cone ribbon synapses in the retina.Pflugers Archiv : European journal of physiology · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Syntaxin 3 is essential for photoreceptor outer segment protein trafficking and survival.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Cassandra L HaysDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska; Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska.
Justin J GrassmeyerDepartment of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska.
Xiangyi WenDepartment of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska; West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Roger JanzDepartment of Neurobiology and Anatomy, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas; The University of Texas MD Anderson Cancer Center University of Texas Health Graduate School of Biomedical Sciences, Houston, Texas.
Ruth HeidelbergerDepartment of Neurobiology and Anatomy, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas; The University of Texas MD Anderson Cancer Center University of Texas Health Graduate School of Biomedical Sciences, Houston, Texas.
Wallace B ThoresonDepartment of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address: wbthores@unmc.edu.
Nebraska Medical Center · USThe University of Texas MD Anderson Cancer Center · USSichuan University · CN

Funding

Mechanisms of Neurotransmisson in Vertebrate RetinaR01EY012128 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HEIDELBERGER, RUTH · 2003 to 2025
$8.0M
Regulation of Photoreceptor NeurotransmisssionR01EY010542 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KARATEKIN, ERDEM, THORESON, WALLACE B · 2001 to 2023
$7.7M
MECHANISMS OF NEUROTRANSMISSION IN VERTEBRATE RETINAR29EY012128 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HEIDELBERGER, RUTH · 1998 to 2002
$343k
Investigating Ca2+ dependent mechanisms of mammalian photoreceptor neurotransmissionF30EY028848 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GRASSMEYER, JUSTIN J · 2018 to 2020
$132k
CHLORIDE REGULATION OF PHOTORECEPTOR NEUROTRANSMISSIONR29EY010542 · NEI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THORESON, WALLACE B · 1996 to 2000
$105k
NEI NIH HHS F30 EY028848NEI NIH HHS R01 EY010542NEI NIH HHS R01 EY012128NEI NIH HHS R29 EY010542NEI NIH HHS R29 EY012128
6 · The paper itself

Abstract

First proposed as a specialized mode of release at sensory neurons possessing ribbon synapses, multivesicular release has since been described throughout the central nervous system. Many aspects of multivesicular release remain poorly understood. We explored mechanisms underlying simultaneous multivesicular release at ribbon synapses in salamander retinal rod photoreceptors. We assessed spontaneous release presynaptically by recording glutamate transporter anion currents (I

Indexed as

SynapsesSynaptic VesiclesExcitatory Postsynaptic PotentialsQa-SNARE ProteinsRetinal Rod Photoreceptor CellsSynaptic TransmissionQa-SNARE Proteins

Identifiers

PMID31653448
PMCPMC7036726
OpenAlexW2979419140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.