Stretch-activated current in human atrial myocytes and Na

Heqing Zhan, Jingtao Zhang, Anquan Jiao, Qin Wang

Open access · goldAbstract read

In one paragraph

Article in Biomedical engineering online, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.3field-weighted citation impact, top 35% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Heqing ZhanCollege of Medical Information, Hainan Medical University, Haikou, 571199, China. zhq86zijing@163.com.ORCID http://orcid.org/0000-0002-3571-2695

Jingtao ZhangCardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Beijing, 100037, China.

Anquan JiaoCollege of Medical Information, Hainan Medical University, Haikou, 571199, China.

Qin WangCollege of Medical Information, Hainan Medical University, Haikou, 571199, China.

Hainan Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHainan Medical College Hospital · CN

Funding

National Natural Science Foundation of China 81501557

6 · The paper itself

Abstract

backgroundThe activation of stretch-activated channels (SACs) in cardiac myocytes, which changes the phases of action potential repolarization, is proven to be highly efficient for the conversion of atrial fibrillation. The expression of Na

resultsOur results indicated that these three currents significantly regulated myocyte mechanical parameters. In isosarcometric contraction, these currents increased segment force by 13.8-36.6% and dropped element length by 12.1-31.5%. In isotonic contraction, there are 2.7-5.9% growth and 0.9-24% reduction. Effects of these currents on the extremum of myocyte mechanical parameters become more significant with the increase of basic cycle length, number of coupled Mfbs and intercellular coupling conductance.

conclusionsThe results demonstrated that stretch-activated current in myocytes and Na

Indexed as

Electrophysiological PhenomenaIon Channel GatingMechanical PhenomenaModels, CardiovascularAction PotentialsBiomechanical PhenomenaHeart AtriaHumansMyocytes, CardiacMyofibroblastsSodiumSodiumMathematical modelingMechano-gated channels (MGCs)Myocyte mechanicsMyofibroblast–myocyte (Mfb–M) couplingStretch-activated channels (SACs)Voltage-gated sodium channels (VGSCs)

Identifiers

PMID31653259

DOI10.1186/s12938-019-0723-5

PMCPMC6814973

OpenAlexW2982243316

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.