ArticleBiomedical engineering online2019
Structural and functional alterations of the tracheobronchial tree after left upper pulmonary lobectomy for lung cancer.
Article in Biomedical engineering online, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Human trachea and bronchi: Structural adaptations in respiratory health.Bioinformation · 2026Article
- Numerical Investigation to Improve Pulmonary Drug Delivery via Dry Powder Inhalers: A Review of In-Silico Modeling.Pharmaceutical research · 2025Review
- Investigation of the physical driving mechanisms of wind noise in hearing devices by computational fluid dynamics.Scientific reports · 2025Article
- Modeling Realistic Geometries in Human Intrathoracic Airways.Diagnostics (Basel, Switzerland) · 2024Review
- Difficult Lung Isolation in a Heavy Smoker With a History of Left Lower Lobectomy: A Case Report.Cureus · 2024Article
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- Relationship between pulmonary blood flow and volume following lung resection using dynamic perfusion digital radiography.Journal of thoracic disease · 2023Article
- Inferior pulmonary ligament division during left upper lobectomy causes pulmonary dysfunction.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- In vitro-in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model.PLoS computational biology · 2023Article
- Automated Detection of Broncho-Arterial Pairs Using CT Scans Employing Different Approaches to Classify Lung Diseases.Biomedicines · 2023Article
- Is the SARS CoV-2 Omicron Variant Deadlier and More Transmissible Than Delta Variant?International journal of environmental research and public health · 2022Review
- Functional analysis of the airways after pulmonary lobectomy through computational fluid dynamics.Scientific reports · 2022Article
- End-to-side anastomosis in complex tracheal resection and reconstruction: a case series study.Translational lung cancer research · 2022Article
- Bronchial morphological changes are associated with postoperative intractable cough after right upper lobectomy in lung cancer patients.Quantitative imaging in medicine and surgery · 2022Article
- Effects of Preserving the Pulmonary Vagus Nerve Branches on Cough After Pneumonectomy During Video-Assisted Thoracic Surgery.Frontiers in oncology · 2022Article
- LncRNA MANCR positively affects the malignant progression of lung adenocarcinoma.BMC pulmonary medicine · 2021Article
- Computational fluid dynamics of the airways after left-upper pulmonary lobectomy: A case study.International journal for numerical methods in biomedical engineering · 2021Article
- Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung.International journal of environmental research and public health · 2021Article
- Risk factors of middle lobe bronchus kinking following right upper lobectomy.Journal of thoracic disease · 2021Article
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundPulmonary lobectomy has been a well-established curative treatment method for localized lung cancer. After left upper pulmonary lobectomy, the upward displacement of remaining lower lobe causes the distortion or kink of bronchus, which is associated with intractable cough and breathless. However, the quantitative study on structural and functional alterations of the tracheobronchial tree after lobectomy has not been reported. We sought to investigate these alterations using CT imaging analysis and computational fluid dynamics (CFD) method.
methodsBoth preoperative and postoperative CT images of 18 patients who underwent left upper pulmonary lobectomy are collected. After the tracheobronchial tree models are extracted, the angles between trachea and bronchi, the surface area and volume of the tree, and the cross-sectional area of left lower lobar bronchus are investigated. CFD method is further used to describe the airflow characteristics by the wall pressure, airflow velocity, lobar flow rate, etc.
resultsIt is found that the angle between the trachea and the right main bronchus increases after operation, but the angle with the left main bronchus decreases. No significant alteration is observed for the surface area or volume of the tree between pre-operation and post-operation. After left upper pulmonary lobectomy, the cross-sectional area of left lower lobar bronchus is reduced for most of the patients (15/18) by 15-75%, especially for 4 patients by more than 50%. The wall pressure, airflow velocity and pressure drop significantly increase after the operation. The flow rate to the right lung increases significantly by 2-30% (but there is no significant difference between each lobe), and the flow rate to the left lung drops accordingly. Many vortices are found in various places with severe distortions.
conclusionsThe favorable and unfavorable adaptive alterations of tracheobronchial tree will occur after left upper pulmonary lobectomy, and these alterations can be clarified through CT imaging and CFD analysis. The severe distortions at left lower lobar bronchus might exacerbate postoperative shortness of breath.
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