Evidence map›Paper›PMID 31653137›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2019

Fecal Genetic Mutations and Human DNA in Colorectal Cancer and Polyps Patients.

Jacqueline Lima, Yolanda Teixeira, Célia Pimenta, Aledson Vitor Felipe, Tiago Donizetti Silva, Ermelindo Ermelindo Della Libera Junior, Sarhan Sydney Saad, Elisabeth Deak, Helena Murray, Nora Manoukian Forones

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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacqueline LimaOncology Group, Gastroenterology Division, Medicine Department, Universidade Federal de Sao Paulo, São Paulo, Brazil.
Yolanda TeixeiraOncology Group, Gastroenterology Division, Medicine Department, Universidade Federal de Sao Paulo, São Paulo, Brazil.
Célia PimentaOncology Group, Gastroenterology Division, Medicine Department, Universidade Federal de Sao Paulo, São Paulo, Brazil.
Aledson Vitor FelipeOncology Group, Gastroenterology Division, Medicine Department, Universidade Federal de Sao Paulo, São Paulo, Brazil.ORCID 0000-0003-1335-1478
Tiago Donizetti SilvaOncology Group, Gastroenterology Division, Medicine Department, Universidade Federal de Sao Paulo, São Paulo, Brazil.
Ermelindo Ermelindo Della Libera JuniorGastroenterology Division and Endoscopist, Universidade Federal de Sao Paulo, São Paulo, Brazil.
Sarhan Sydney SaadSurgery Department, Universidade Federal de Sao Paulo, São Paulo, Brazil.
Elisabeth DeakSurgery Department, Universidade Federal de Sao Paulo, São Paulo, Brazil.
Helena MurrayRandox Laboratories Ltd., Crumlin, Co. Antrim, United Kingdom.
Nora Manoukian ForonesOncology Group, Gastroenterology Division, Medicine Department, Universidade Federal de Sao Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is one of the most frequent cancers. Genetic mutations in CRC already described can be detected in feces. Microarray methods in feces can represent a new diagnostic tool for CRC and significant improvement at public health.

aimto analyze stool DNA by human DNA quantify and microarray methods as alternatives to CRC screening.

methodThree methods were analyzed in stool samples: Human DNA Quantify, RanplexCRC and KRAS/BRAF/PIK3CA (KBP) Arrays.

resultsKBP array mutations were presented in 60.7% of CRC patients and RanplexCRC Array mutations in 61.1% of CRC patients. Sensitivity and specificity for human DNA quantification was 66% and 82% respectively. Fecal KBP Array had 35% sensitivity and 96% specificity and RanplexCRC Array method had 78% sensitivity and 100% specificity.

conclusionMicroarray methods showed promise as potential biomarkers for CRC screening; however, these methods had to be optimized to improve accuracy and applicability by clinical routine.

Indexed as

MutationAgedBiomarkers, TumorCase-Control StudiesColonic PolypsColonoscopyColorectal NeoplasmsDNA, NeoplasmEarly Detection of CancerFecesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisBiomarkers, TumorBRAF protein, humanDNA, NeoplasmKRAS protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)colonoscopycolorectal cancerPolypsScreeningStool DNA

Identifiers

PMID31653137
PMCPMC6982689

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.