Evidence map›Paper›PMID 31653122›Full record

ArticleViruses2019

Effects of Regulatory T Cell Depletion on NK Cell Responses against

Rita D Simões, Alora LaVoy, Gregg A Dean

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Recognition ofInnate immunity · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rita D SimõesCenter for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA. rdsimoes@ncsu.edu.
Alora LaVoyCenter for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA. alora.lavoy@colostate.edu.
Gregg A DeanCenter for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA. Gregg.dean@colostate.edu.
North Carolina State University · US

Funding

BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIVR01AI047707 · NIAID · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DEAN, GREGG A · 2001 to 2010
$2.5M
NIAID NIH HHS R01AI047707
6 · The paper itself

Abstract

Regulatory T cells (Treg) are key players in the maintenance of peripheral tolerance, preventing autoimmune diseases and restraining chronic inflammatory diseases. Evidence suggests Treg cells and NK cells have important roles in feline immunodeficiency virus (FIV) pathogenesis; however, in vivo studies investigating the interplay between these two cell populations are lacking. We previously described innate immune defects in FIV-infected cats characterized by cytokine deficits and impaired natural killer cell (NK) and NK T cell (NKT) functions. In this study, we investigated whether in vivo Treg depletion by treatment with an anti-feline CD25 monoclonal antibody would improve the innate immune response against subcutaneous challenge with

Indexed as

AnimalsCatsDendritic CellsFeline Acquired Immunodeficiency SyndromeFemaleImmunodeficiency Virus, FelineKiller Cells, NaturalListeria monocytogenesListeriosisLymph NodesLymphocyte DepletionOpportunistic InfectionsT-Lymphocytes, Regulatoryfeline immunodeficiency virusinnate immunityNK cellsregulatory T cellsTreg depletion

Identifiers

PMID31653122
PMCPMC6893779
OpenAlexW2981881129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.