Evidence map›Paper›PMID 31653077›Full record

ArticleVaccines2019

Dissolving Microneedles for Intradermal Vaccination against Shigellosis.

Yadira Pastor, Eneko Larrañeta, Álvaro Erhard, Gemma Quincooces, Iván Peñuelas, Juan M Irache, Ryan Donnelly, Carlos Gamazo

Abstract read
In one paragraph

Article in Vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Poly(methyl vinyl ether-Polymers · 2026
    Review
  2. Review
  3. Advances in clinical applications of microneedle.Frontiers in pharmacology · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Progress in Microneedle-Mediated Protein Delivery.Journal of clinical medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yadira PastorDepartment of Microbiology and Parasitology, Institute of Tropical Health, University of Navarra, 31008 Pamplona, Spain. ypastor@alumni.unav.es.
Eneko LarrañetaSchool of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Northern Ireland, Belfast BT9 7BL, UK. e.larraneta@qub.ac.uk.
Álvaro ErhardSchool of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Northern Ireland, Belfast BT9 7BL, UK. aerhard@unav.es.
Gemma QuincoocesDepartment of Nuclear Medicine, Clínica Universidad de Navarra, 31008 Pamplona, Spain. gquinfer@unav.es.
Iván PeñuelasDepartment of Nuclear Medicine, Clínica Universidad de Navarra, 31008 Pamplona, Spain. ipenuelas@unav.es.
Juan M IracheInstitute of Tropical Health, University of Navarra, 31008 Pamplona, Spain. jmirache@unav.es.
Ryan DonnellySchool of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Northern Ireland, Belfast BT9 7BL, UK. R.Donnelly@qub.ac.uk.
Carlos GamazoDepartment of Microbiology and Parasitology, Institute of Tropical Health, University of Navarra, 31008 Pamplona, Spain. cgamazo@unav.es.

Funding

Instituto de Salud Carlos III", the European Regional Development Fund (ERDF) PI16/00071
6 · The paper itself

Abstract

Intradermal (ID) immunization is of increasing interest due to the easy accessibility and excellent immunogenic properties of the skin. Among ID immunization methods, dissolving microneedles (MNs) have appeared as an alternative to traditional hypodermic immunization, offering many advantages, such as being an easily administered method, with no need for health personnel, painless, and avoiding the use of needles and sharp wastage. In this study, an affordable and easy-to-produce MNs method was developed based on aqueous blends of 30% w/w poly (methyl vinyl ether-co-maleic anhydride). As an antigen model, a subunit vaccine candidate based on outer membrane vesicles from

Indexed as

Dissolving MicroneedlesIntradermalouter membrane vesiclesShigellaVaccine

Identifiers

PMID31653077
PMCPMC6963400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.