Evidence map›Paper›PMID 31653023›Full record

ArticleAntioxidants (Basel, Switzerland)2019

The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study.

André Sperl, Raban Arved Heller, Bahram Biglari, Patrick Haubruck, Julian Seelig, Lutz Schomburg, Tobias Bock, Arash Moghaddam

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits.Oxidative medicine and cellular longevity · 2024
    Review
  7. Magnesium (MgCurrent pharmaceutical design · 2024
    Review
  8. Electrolyte Imbalance and Neurologic Injury.CNS & neurological disorders drug targets · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. 'Magnesium'-the master cation-as a drug-possibilities and evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021
    Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

André SperlHeidelberg Trauma Research Group, Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 06221 Heidelberg, Germany. andre.sperl@gmx.de.ORCID 0000-0001-8069-8389
Raban Arved HellerHeidelberg Trauma Research Group, Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 06221 Heidelberg, Germany. Raban.Heller@med.uni-heidelberg.de.
Bahram BiglariBerfsgenssenschaftliche Unfallklink Trauma Centre Ludwigshafen, Department of Paraplegiology, Head of the Department, 0621 Ludwigshafen, Germany. bahram.biglari@bgu-ludwigshafen.de.
Patrick HaubruckHeidelberg Trauma Research Group, Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 06221 Heidelberg, Germany. patrick.haubruck@sydney.edu.au.
Julian SeeligInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany. julian.seelig@charite.de.
Lutz SchomburgInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany. lutz.schomburg@charite.de.ORCID 0000-0001-9445-1555
Tobias BockHeidelberg Trauma Research Group, Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 06221 Heidelberg, Germany. tobias.bock@stud.uni-heidelberg.de.
Arash MoghaddamAschaffenburg Trauma and Orthopedic Research Group, Center for Orthopedics, Trauma Surgery and Sports Medicine, Hospital Aschaffenburg-Alzenau, 63739 Aschaffenburg, Germany. Arash.Moghaddam-Alvandi@klinikum-ab-alz.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the secondary injury phase after traumatic spinal cord injury (TSCI), oxidative stress and neuroinflammatory responses at the site of injury constitute crucial factors controlling damage extent and may serve as potential therapeutic targets. We determined Magnesium (Mg) serum concentration dynamics in context with the potential of neurological remission in patients with TSCI as Mg is suspected to limit the production of reactive oxygen species and reduce lipid peroxidation. A total of 29 patients with acute TSCI were enrolled, and blood samples were drawn over 3 months at 11 time-points and Mg quantification was performed. Patients were divided into those with (G1,

Indexed as

Magnesiumneuroprotectionneurotraumaregenerationtraumatic spinal cord injury

Identifiers

PMID31653023
PMCPMC6912766

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.