Evidence map›Paper›PMID 31652996›Full record

ArticleMaterials (Basel, Switzerland)2019

The Implantation of Bioactive Glass Granules Can Contribute the Load-Bearing Capacity of Bones Weakened by Large Cortical Defects.

Nicole A P van Gestel, Floor Gabriels, Jan A P Geurts, Dennis J W Hulsen, Caroline E Wyers, Joop P van de Bergh, Keita Ito, Sandra Hofmann, Jacobus J Arts, Bert van Rietbergen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicole A P van GestelOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. n.a.p.v.gestel@tue.nl.ORCID 0000-0003-0162-490X
Floor GabrielsOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. floor.gabriels@log-ten.com.
Jan A P GeurtsDepartment of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, PO Box 5800, 6229 HX Maastricht, The Netherlands. j.geurts@mumc.nl.ORCID 0000-0002-0973-572X
Dennis J W HulsenOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. d.hulsen@jbz.nl.ORCID 0000-0002-0850-1999
Caroline E WyersDepartment of Internal Medicine, VieCuri Medical Center, Tegelseweg 210, 5912 BL Venlo, The Netherlands. cwyers@viecuri.nl.ORCID 0000-0001-7662-3990
Joop P van de BerghDepartment of Internal Medicine, VieCuri Medical Center, Tegelseweg 210, 5912 BL Venlo, The Netherlands. jvdbergh@viecuri.nl.
Keita ItoOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. k.ito@tue.nl.ORCID 0000-0002-7372-4072
Sandra HofmannOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. s.hofmann@tue.nl.
Jacobus J ArtsOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. j.arts@mumc.nl.
Bert van RietbergenOrthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. b.v.rietbergen@tue.nl.

Funding

Women in Science and Engineering, Eindhoven University of Technology WISE-2014-1004081
6 · The paper itself

Abstract

Bioactive glass (BAG) granules (S53P4) have shown good clinical results in one-stage treatment of osteomyelitis. During this treatment, a cortical window is created, and infected bone is debrided, which results in large defects that affect the mechanical properties of the bone. This study aimed to evaluate the role of BAG granules in load-bearing bone defect grafting. First, the influence of the geometry of the cortical window on the bone bending stiffness and estimated failure moments was evaluated using micro finite element analysis (µFE). This resulted in significant differences between the variations in width and length. In addition, µFE analysis showed that BAG granules contribute to bearing loads in simulated compression of a tibia with a defect grafted with BAG and a BAG and bone morsel mixture. These mixtures potentially can unload the cortical bone that is weakened by a large defect directly after the operation by up to approximately 25%, but only in case of optimal load transfer through the mixture.

Indexed as

bioactive glass granulesfinite element analysisload sharingmechanical propertiesosteomyelitisstiffnesstreatment

Identifiers

PMID31652996
PMCPMC6862453

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.