Evidence map›Paper›PMID 31652977›Full record

ArticlePolymers2019

Albumin-Enriched Fibrin Hydrogel Embedded in Active Ferromagnetic Networks Improves Osteoblast Differentiation and Vascular Self-Organisation.

Galit Katarivas Levy, John Ong, Mark A Birch, Alexander W Justin, Athina E Markaki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Galit Katarivas LevyDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK. gk406@cam.ac.uk.ORCID 0000-0003-4711-7348
John OngDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK. jo401@cam.ac.uk.ORCID 0000-0001-5103-7311
Mark A BirchDivision of Trauma and Orthopaedic Surgery, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. mab218@cam.ac.uk.
Alexander W JustinDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK. awj27@cam.ac.uk.
Athina E MarkakiDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK. am253@cam.ac.uk.ORCID 0000-0002-2265-1256
University of Cambridge · GBAddenbrooke's Hospital · GB

Funding

Blavatnik Family Foundation xxxEngineering and Physical Sciences Research Council EP/R511675/1Isaac Newton Trust M787Reuben Foundation xxxRosetrees Trust M787WD Armstrong Doctoral Fellowship xxx
6 · The paper itself

Abstract

Porous coatings on prosthetic implants encourage implant fixation. Enhanced fixation may be achieved using a magneto-active porous coating that can deform elastically in vivo on the application of an external magnetic field, straining in-growing bone. Such a coating, made of 444 ferritic stainless steel fibres, was previously characterised in terms of its mechanical and cellular responses. In this work, co-cultures of human osteoblasts and endothelial cells were seeded into a novel fibrin-based hydrogel embedded in a 444 ferritic stainless steel fibre network. Albumin was successfully incorporated into fibrin hydrogels improving the specific permeability and the diffusion of fluorescently tagged dextrans without affecting their Young's modulus. The beneficial effect of albumin was demonstrated by the upregulation of osteogenic and angiogenic gene expression. Furthermore, mineralisation, extracellular matrix production, and formation of vessel-like structures were enhanced in albumin-enriched fibrin hydrogels compared to fibrin hydrogels. Collectively, the results indicate that the albumin-enriched fibrin hydrogel is a promising bio-matrix for bone tissue engineering and orthopaedic applications.

Indexed as

ferromagnetic fibre networkfibrin hydrogelhuman albuminhuman endothelial cellshuman foetal osteoblasts

Identifiers

PMID31652977
PMCPMC6918167
OpenAlexW2973285604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.