Evidence map›Paper›PMID 31652947›Full record

ArticleCells2019

Off-Target Deletion of Conditional

Chichu Xie, Fangming Zhu, Julie Wang, Weizhou Zhang, Joseph A Bellanti, Bin Li, David Brand, Nancy Olsen, Song Guo Zheng

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Chichu XieDepartment of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. chichu.xie@outlook.com.
Fangming ZhuShanghai Key Laboratory of Bio-Energy Crops, School of Life Science, Shanghai University, Shanghai 200025, China. fmzhu@ips.ac.cn.
Julie WangDepartment of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH 43210, USA. Julie.Wang@osumc.edu.
Weizhou ZhangDepartment of Pathology, Immunology and Laboratory Medicine UF Health Cancer Center, Gainesville, FL 32610, USA. zhangw@ufl.edu.ORCID 0000-0002-8236-0346
Joseph A BellantiDepartment of Pediatrics and Microbiology-Immunology, Georgetown University Medical Center, Washington, DC 20057, USA. bellantj@georgetown.edu.ORCID 0000-0002-5038-7202
Bin LiShanghai Institute of Immunology and Department of Immunology and Microbiology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. binli@shsmu.edu.cn.
David BrandResearch Service, Memphis VA Medical Center, Memphis, TN 38104, USA. dbrand@uthsc.edu.ORCID 0000-0002-9260-7963
Nancy OlsenDepartment of Medicine, Penn State University Hershey College of Medicine, Hershey, PA 17033, USA. nolsen@pennstatehealth.psu.edu.
Song Guo ZhengDepartment of Internal Medicine, Ohio State University College of Medicine and Wexner Medical Center, Columbus, OH 43210, USA. SongGuo.Zheng@osumc.edu.ORCID 0000-0002-5611-4774
The Ohio State University Wexner Medical Center · USGeorgetown University · USMemphis VA Medical Center · USPenn State Milton S. Hershey Medical Center · USShanghai University · CNSun Yat-sen University · CNUniversity of Florida Health · US

Funding

Therapeutic immunoregulation mediated by TGF-??-induced iTregs in autoimmune arthR01AR059103 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JARJOUR, WAEL N · 2010 to 2020
$3.9M
Obesity, inflammation and breast cancerR01CA200673 · NCI · UNIVERSITY OF IOWA · PI ZHANG, WEIZHOU · 2016 to 2020
$1.7M
CD177 suppresses breast-cancer development by inhibiting beta-cateninR01CA203834 · NCI · UNIVERSITY OF IOWA · PI ZHANG, WEIZHOU · 2016 to 2020
$1.7M
NCI NIH HHS R01 CA200673NCI NIH HHS R01 CA203834NIAMS NIH HHS R01 AR059103
6 · The paper itself

Abstract

The Cre-LoxP conditional knockout strategy has been used extensively to study gene function in a specific cell-type. In this study, the authors tried to engineer mice in which the

Indexed as

AllelesAnimalsCell Cycle ProteinsFemaleForkhead Transcription FactorsGenetic EngineeringGenotypeGerm CellsIntegrasesMaleMiceMice, KnockoutMice, TransgenicNerve Tissue ProteinsPhenotypePromoter Regions, GeneticBRINP1 protein, mouseCell Cycle ProteinsCre recombinaseForkhead Transcription FactorsFOXP3 protein, humanFoxp3 protein, mouseIntegrasesNerve Tissue ProteinsCreFoxp3Germline recombinationOff-target

Identifiers

PMID31652947
PMCPMC6912351
OpenAlexW2981459939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.