ArticleMetabolites2019
Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion.
Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Evaluation of Liver Grafts During Machine Perfusion at 20°C via Metabolization of 13C-Methacetin.European journal of clinical investigation · 2026Article
- Cellular and Molecular Changes Induced by Various Preservation Temperatures and Methods of Preservation in Renal Grafts and Other Solid Organ Grafts.International journal of molecular sciences · 2026Review
- Optimizing DCD donor liver function with resveratrol during machine perfusion.Scientific reports · 2025Article
- Organ preservation: current limitations and optimization approaches.Frontiers in medicine · 2025Review
- High intake of n-6 polyunsaturated fatty acid exacerbates non-alcoholic steatohepatitis by the involvement of multiple metabolic pathways.Frontiers in nutrition · 2025Article
- How to Preserve Steatotic Liver Grafts for Transplantation.Journal of clinical medicine · 2023Review
- Changing liver utilization and discard rates in clinical transplantation in the ex-vivo machine preservation era.Frontiers in medical technology · 2023Review
- Current practice and novel approaches in organ preservation.Frontiers in transplantation · 2023Review
- Recent Methods of Kidney Storage and Therapeutic Possibilities of Transplant Kidney.Biomedicines · 2022Review
- Research progress on hepatic machine perfusion.International journal of medical sciences · 2021Review
- The Role of Metabolomics in Current Concepts of Organ Preservation.International journal of molecular sciences · 2020Review
- Tryptophan Metabolism via the Kynurenine Pathway: Implications for Graft Optimization during Machine Perfusion.Journal of clinical medicine · 2020Article
- Restoring Mitochondrial Function While Avoiding Redox Stress: The Key to Preventing Ischemia/Reperfusion Injury in Machine Perfused Liver Grafts?International journal of molecular sciences · 2020Review
- A Review of Machine Perfusion Strategies in Liver Transplantation.Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
There continues to be significant debate regarding the most effective mode of ex situ machine perfusion of livers for transplantation. Subnormothermic (SNMP) and normothermic machine perfusion (NMP) are two methods with different benefits. We examined the metabolomic profiles of discarded steatotic human livers during three hours of subnormothermic or normothermic machine perfusion. Steatotic livers regenerate higher stores of ATP during SNMP than NMP. However, there is a significant depletion of available glutathione during SNMP, likely due to an inability to overcome the high energy threshold needed to synthesize glutathione. This highlights the increased oxidative stress apparent in steatotic livers. Rescue of discarded steatotic livers with machine perfusion may require the optimization of redox status through repletion or supplementation of reducing agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.