ArticleJournal of fungi (Basel, Switzerland)2019
Ongoing Challenges with Healthcare-Associated Candida auris Outbreaks in Oman.
Article in Journal of fungi (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Candida auris-a systematic review to inform the world health organization fungal priority pathogens list.Medical mycology · 2024Pooled it
- Pooled it
- Review
- Article
- Surface-associatedFrontiers in cellular and infection microbiology · 2026Article
- A study of genomic complexity underlying multidrug resistance in Candida auris strains in Thailand.Scientific reports · 2025Article
- Risk factors associated withEpidemiology and infection · 2025Article
- Review
- Patterns and Predictors ofJournal of fungi (Basel, Switzerland) · 2025Article
- Candida auris central line-associated blood stream infection in critically ill patients: the worst end of a bad scenario.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Current Perspectives of Antifungal Therapy: A Special Focus onJournal of fungi (Basel, Switzerland) · 2024Review
- Potential Environmental Reservoirs ofJournal of fungi (Basel, Switzerland) · 2024Review
- Article
- The many faces of Candida auris: Phenotypic and strain variation in an emerging pathogen.PLoS pathogens · 2024Review
- Spectrum of infection and outcomes in individuals with Candida auris infection in Qatar.PloS one · 2024Article
- The Gordian Knot ofPathogens (Basel, Switzerland) · 2023Review
- Description ofHealthcare (Basel, Switzerland) · 2023Article
- Candida auris Blood stream infection- a descriptive study from Qatar.BMC infectious diseases · 2023Article
- Review
- Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida auris has emerged in the past decade as a multi-drug resistant public health threat causing health care outbreaks. Here we report epidemiological, clinical, and microbiological investigations of a C. auris outbreak in a regional Omani hospital between April 2018 and April 2019. The outbreak started in the intensive care areas (intensive care unit (ICU), coronary care unit (CCU), and high dependency unit) but cases were subsequently diagnosed in other medical and surgical units. In addition to the patients' clinical and screening samples, environmental swabs from high touch areas and from the hands of 35 staff were collected. All the positive samples from patients and environmental screening were confirmed using MALDI-TOF, and additional ITS-rDNA sequencing was done for ten clinical and two environmental isolates. There were 32 patients positive for C. auris of which 14 (43.8%) had urinary tract infection, 11 (34.4%) had candidemia, and 7 (21.8%) had asymptomatic skin colonization. The median age was 64 years (14-88) with 17 (53.1%) male and 15 (46.9%) female patients. Prior to diagnosis, 21 (65.6%) had been admitted to the intensive care unit, and 11 (34.4%) had been nursed in medical or surgical wards. The crude mortality rate in our patient's cohort was 53.1. Two swabs collected from a ventilator in two different beds in the ICU were positive for C. auris. None of the health care worker samples were positive. Molecular typing showed that clinical and environmental isolates were genetically similar and all belonged to the South Asian C. auris clade I. Most isolates had non-susceptible fluconazole (100%) and amphotericin B (33%) minimal inhibitory concentrations (MICs), but had low echinocandin and voriconazole MICs. Despite multimodal infection prevention and control measures, new cases continued to appear, challenging all the containment efforts.
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