Evidence map›Paper›PMID 31652739›Full record

ReviewInternational journal of molecular sciences2019

Casting a Wider Net: Differentiating between Inner Nuclear Envelope and Outer Nuclear Envelope Transmembrane Proteins.

Mark Tingey, Krishna C Mudumbi, Eric C Schirmer, Weidong Yang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Nuclear envelope budding: Getting large macromolecular complexes out of the nucleus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Article
  3. Article
  4. Molecular Mechanisms for the Regulation of Nuclear Membrane Integrity.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Unraveling docking and initiation of mRNA export through the nuclear pore complex.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
    Article
  10. Article
  11. The Physical Chemistry and Chemical Physics (PCCP) Section of theInternational journal of molecular sciences · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Ion and Molecule Transport in Membrane Systems.International journal of molecular sciences · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Mark TingeyDepartment of Biology, Temple University, Philadelphia, PA 19121, USA. Mark.Tingey@temple.edu.ORCID 0000-0002-0365-5585
Krishna C MudumbiDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA. Krishna.Mudumbi@yale.edu.
Eric C SchirmerWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH8 3BF, UK. E.Schirmer@ed.ac.uk.ORCID 0000-0003-2635-1338
Weidong YangDepartment of Biology, Temple University, Philadelphia, PA 19121, USA. Weidong.Yang@temple.edu.ORCID 0000-0002-3649-1863
Temple University · USWellcome Centre for Cell Biology · GBYale Cancer Center · US

Funding

Super-resolution Microscopy Study of Molecular Transport MechanismsR35GM122552 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Weidong Yang · 2017 to 2026
$4.5M
Structure and Function of the Ciliary Pore ComplexR01GM116204 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VERHEY, KRISTEN J., YANG, WEIDONG · 2015 to 2018
$2.1M
Foundation for the National Institutes of Health NIH GM097037, GM116204 and RGM122552Medical Research Council MR/R018073/1NIGMS NIH HHS R35 GM122552
6 · The paper itself

Abstract

The nuclear envelope (NE) surrounds the nucleus with a double membrane in eukaryotic cells. The double membranes are embedded with proteins that are synthesized on the endoplasmic reticulum and often destined specifically for either the outer nuclear membrane (ONM) or the inner nuclear membrane (INM). These nuclear envelope transmembrane proteins (NETs) play important roles in cellular function and participate in transcription, epigenetics, splicing, DNA replication, genome architecture, nuclear structure, nuclear stability, nuclear organization, and nuclear positioning. These vital functions are dependent upon both the correct localization and relative concentrations of NETs on the appropriate membrane of the NE. It is, therefore, important to understand the distribution and abundance of NETs on the NE. This review will evaluate the current tools and methodologies available to address this important topic.

Indexed as

AnimalsHumansMembrane ProteinsMolecular ImagingNuclear EnvelopeOptical ImagingMembrane Proteinsinner nuclear membraneNETsnuclear envelopeouter nuclear membrane

Identifiers

PMID31652739
PMCPMC6862087
OpenAlexW2981908542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.