ReviewNutrients2019
Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- Weight Loss and Exercise Differentially Affect Insulin Sensitivity, Body Composition, Cardiorespiratory Fitness, and Muscle Strength in Older Adults With Obesity: A Randomized Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Shatavari Supplementation in Postmenopausal Women Improves Handgrip Strength and IncreasesNutrients · 2021Trial
- Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate (HMB) Improves Nutrition, Physical Performance and Ameliorates Intramuscular Adiposity in Pre-Frail Older Adults: A Randomized Controlled Trial.The journal of nutrition, health & aging · 2021Trial
- Dysferlin promotes inflammatory macrophage responses and modulates CaLife science alliance · 2026Article
- Effects of Cryopreservation on Stromal Vascular Fraction Viability in Human Adipose Tissue: Insights from a Systematic Review.Tissue engineering and regenerative medicine · 2026Review
- Associations of obesity phenotypes with incident fall rates: results from the objective physical activity and cardiovascular disease health in older women study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Beyond Adiposity: Lean Mass and Bone Mineral Content as Markers of Muscle Weakness and Physical Performance in Older Adults.Medicina (Kaunas, Lithuania) · 2026Article
- Skeletal muscle as a dynamic immunological niche for vaccination.Frontiers in immunology · 2026Review
- Adipose tissue aging as a risk factor for metabolic organ abnormalities: mechanistic insights and the role of exercise interventions.Lipids in health and disease · 2025Review
- Sarcopenia is associated with lower quality of life scores among community-dwelling older Filipinos: Findings from a cross-sectional study.The Journal of frailty & aging · 2025Article
- Body Composition and Its Outcomes and Management in Multiple Sclerosis: Narrative Review.Nutrients · 2025Review
- Factors influencing changes in body composition and nutritional status in patients with hyperacute stroke: prospective study.Frontiers in nutrition · 2025Article
- Non-linear associations and threshold effects of BRI, CI, and WHtR with grip strength in U. S. adults aged ≥20 years: a cross-sectional study.Frontiers in nutrition · 2025Article
- Relationships between trunk tissue distribution, metabolic risk factors and physical performance in young people-A pilot study.Clinical physiology and functional imaging · 2025Article
- Review
- Sarcopenic obesity in patients awaiting liver transplant: Unique challenges for nutritional recommendations.World journal of transplantation · 2024Review
- Unraveling the roles of ectopic adipose depots and physical activity in age-related mitochondrial decline.Obesity (Silver Spring, Md.) · 2024Article
- %BF, Rather Than BMI, is Associated with an Increased Risk of Sarcopenia in Hospitalized Postmenopausal Chinese Women with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Physiological Approaches Targeting Cellular and Mitochondrial Pathways Underlying Adipose Organ Senescence.International journal of molecular sciences · 2023Review
- Characteristic and fate determination of adipose precursors during adipose tissue remodeling.Cell regeneration (London, England) · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interplay between adipose tissue and skeletal muscle and the impact on mobility and aging remain enigmatic. The progressive decline in mobility promoted by aging has been previously attributed to the loss of skeletal mass and function and more recently linked to changes in body fat composition and quantity. Regardless of body size, visceral and intermuscular adipose depots increase with aging and are associated with adverse health outcomes. However, the quality of adipose tissue, in particular abdominal subcutaneous as it is the largest depot, likely plays a significant role in aging outcomes, such as mobility decline, though its communication with other tissues such as skeletal muscle. In this review, we discuss the age-associated development of a pro-inflammatory profile, cellular senescence, and metabolic inflexibility in abdominal subcutaneous adipose tissue. Collectively, these facets of adipose tissue quality influence its secretory profile and crosstalk with skeletal muscle and likely contribute to the development of muscle atrophy and disability. Therefore, the identification of the key structural and functional components of adipose tissue quality-including necrosis, senescence, inflammation, self-renewal, metabolic flexibility-and adipose tissue-secreted proteins that influence mobility via direct effects on skeletal muscle are necessary to prevent morbidity/mortality in the aging population.
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