ArticleMaterials (Basel, Switzerland)2019
Calcium Phosphate Bone Graft Substitutes with High Mechanical Load Capacity and High Degree of Interconnecting Porosity.
Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Bioglasses Versus Bioactive Calcium Phosphate Derivatives as Advanced Ceramics in Tissue Engineering: Comparative and Comprehensive Study, Current Trends, and Innovative Solutions.Journal of functional biomaterials · 2025Review
- Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head.Materials today. Bio · 2025Review
- Fabrication and Evaluation of PCL/PLGA/β-TCP Spiral-Structured Scaffolds for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2024Article
- Multifunctional Three-Dimensional Printed Copper Loaded Calcium Phosphate Scaffolds for Bone Regeneration.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Protocol for Cell Colonization and Comprehensive Monitoring of Osteogenic Differentiation in 3D Scaffolds Using Biochemical Assays and Multiphoton Imaging.International journal of molecular sciences · 2023Article
- Optimized Method of 3D Scaffold Seeding, Cell Cultivation, and Monitoring Cell Status for Bone Tissue Engineering.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes.Materials (Basel, Switzerland) · 2021Article
- Structural Design Method for Constructions: Simulation, Manufacturing and Experiment.Materials (Basel, Switzerland) · 2021Article
- Special Issue "Novel Research about Biomechanics and Biomaterials Used in Hip, Knee and Related Joints".Materials (Basel, Switzerland) · 2021Article
- Setting Characteristics and High Compressive Strength of an Anti-washout, Injectable Calcium Phosphate Cement Combined with Thermosensitive Hydrogel.Materials (Basel, Switzerland) · 2020Article
- Primary Stability of Revision Acetabular Reconstructions Using an Innovative Bone Graft Substitute: A Comparative Biomechanical Study on Cadaveric Pelvises.Materials (Basel, Switzerland) · 2020Article
- Design and Optimization Lattice Endoprosthesis for Long Bones: Manufacturing and Clinical Experiment.Materials (Basel, Switzerland) · 2020Article
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7 authors.
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Abstract
Bone graft substitutes in orthopedic applications have to fulfill various demanding requirements. Most calcium phosphate (CaP) bone graft substitutes are highly porous to achieve bone regeneration, but typically lack mechanical stability. This study presents a novel approach, in which a scaffold structure with appropriate properties for bone regeneration emerges from the space between specifically shaped granules. The granule types were tetrapods (TEPO) and pyramids (PYRA), which were compared to porous CaP granules (CALC) and morselized bone chips (BC). Bulk materials of the granules were mechanically loaded with a peak pressure of 4 MP; i.e., comparable to the load occurring behind an acetabular cup. Mechanical loading reduced the volume of CALC and BC considerably (89% and 85%, respectively), indicating a collapse of the macroporous structure. Volumes of TEPO and PYRA remained almost constant (94% and 98%, respectively). After loading, the porosity was highest for BC (46%), lowest for CALC (25%) and comparable for TEPO and PYRA (37%). The pore spaces of TEPO and PYRA were highly interconnected in a way that a virtual object with a diameter of 150 µm could access 34% of the TEPO volume and 36% of the PYRA volume. This study shows that a bulk of dense CaP granules in form of tetrapods and pyramids can create a scaffold structure with load capacities suitable for the regeneration of an acetabular bone defect.
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