Evidence map›Paper›PMID 31652675›Full record

ArticleMolecules (Basel, Switzerland)2019

Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol.

Naoko Takenaga, Toshitaka Shoji, Takayuki Menjo, Akiko Hirai, Shohei Ueda, Kotaro Kikushima, Tomonori Hanasaki, Toshifumi Dohi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Modern Strategies for Heterocycle Synthesis.Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Naoko TakenagaFaculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan. ntakenag@meijo-u.ac.jp.ORCID 0000-0003-3776-9406
Toshitaka ShojiCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. ph0088sh@ed.ritsumei.ac.jp.
Takayuki MenjoDepartment of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. sb0067xs@ed.ritsumei.ac.jp.
Akiko HiraiCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. akiko.xp@gmail.com.
Shohei UedaDepartment of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. sc0029ev@ed.ritsumei.ac.jp.
Kotaro KikushimaCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. kixy@fc.ritsumei.ac.jp.
Tomonori HanasakiDepartment of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. hanasaki@sk.ritsumei.ac.jp.ORCID 0000-0002-7112-9536
Toshifumi DohiCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. td1203@ph.ritsumei.ac.jp.ORCID 0000-0002-2812-9581
Ritsumeikan University · JPMeijo University · JP

Funding

Japan Society for the Promotion of Science 16K18854Japan Society for the Promotion of Science 19K05466
6 · The paper itself

Abstract

Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and reagents for the syntheses of aryl-substituted purine analogues.

Indexed as

CatalysisHydrocarbons, FluorinatedPurinesStereoisomerismHydrocarbons, FluorinatedPurinesaromatic substitutionarylationfluoroalcoholnucleobasepurine

Identifiers

PMID31652675
PMCPMC6865213
OpenAlexW2981658527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.