Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 5 institutions in 1 country.
Juan Pablo González-GutiérrezDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 8380492 Santiago, Chile. jpgonzalezg@ug.uchile.cl.
Hernán Armando Pessoa-MahanaDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 8380492 Santiago, Chile. hpessoa@ciq.uchile.cl.
Patricio Ernesto Iturriaga-VásquezDepartamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería y Ciencias, Universidad de la Frontera, 4811230 Temuco, Chile. patricio.iturriaga@ufrontera.cl.ORCID 0000-0003-0553-1014
Miguel Iván Reyes-ParadaCentro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, 9170022 Santiago, Chile. miguel.reyes@usach.cl.ORCID 0000-0002-2376-990X
Nicolas Esteban Guerra-DíazDepartamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 8380492 Santiago, Chile. niko.g.diaz@gmail.com.
Martin Hodar-SalazarDepartamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería y Ciencias, Universidad de la Frontera, 4811230 Temuco, Chile. martinhodar@gmail.com.ORCID 0000-0002-4266-5647
Franco ViscarraDepartamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería y Ciencias, Universidad de la Frontera, 4811230 Temuco, Chile. franco.viscarra@gmail.com.
Pablo PaillaliDepartamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería y Ciencias, Universidad de la Frontera, 4811230 Temuco, Chile. p.paillali01@ufromail.cl.
Gabriel Núñez-VivancoCentro de Bioinformática y Simulación Molecular, Universidad de Talca, 3340000 Talca, Chile. gabioin@gmail.com.
Marcos Antonio Lorca-CarvajalInstituto de Química y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, 2360102 Valparaíso, Chile. marcos.lorca.c@gmail.com.ORCID 0000-0003-3729-0980
Jaime Mella-RaipánInstituto de Química y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, 2360102 Valparaíso, Chile. jaime.mella@uv.cl.ORCID 0000-0002-2434-8461
María Carolina ZúñigaDepartamento de Química Inorgánica and Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, 8380492 Santiago, Chile. mczuniga@ciq.uchile.cl.
Universidad de La Frontera · CLUniversity of Chile · CLUniversity of Valparaíso · CLUniversidad de Santiago de Chile · CLUniversity of Talca · CL
Funding
Fondo Nacional de Desarrollo Científico y Tecnológico 1170269
6 · The paper itself
Abstract
Nicotinic acetylcholine receptors (nAChRs), serotonin transporters (SERT) and dopamine transporters (DAT) represent targets for the development of novel nicotinic derivatives acting as multiligands associated with different health conditions, such as depressive, anxiety and addiction disorders. In the present work, a series of functionalized esters structurally related to acetylcholine and nicotine were synthesized and pharmacologically assayed with respect to these targets. The synthesized compounds were studied in radioligand binding assays at α4β2 nAChR, h-SERT and h-DAT. SERT experiments showed not radioligand [
Indexed as
AcetylcholineAllosteric RegulationBinding SitesDopamineDopamine AgonistsDopamine Plasma Membrane Transport ProteinsEstersHEK293 CellsHumansLigandsMolecular Docking SimulationNicotineNicotinic AgonistsPyrrolidinesRadioligand AssayReceptors, NicotinicAcetylcholineDopamineDopamine AgonistsDopamine Plasma Membrane Transport ProteinsEstersLigandsNicotineNicotinic Agonistsnicotinic receptor alpha4beta2pyrrolidinePyrrolidinesReceptors, NicotinicSerotonin Plasma Membrane Transport Proteinsaffinityallosteric modulatorsDATnAChRSERTα4β2
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters. · full record | OpenQuestion