ReviewJournal of clinical medicine2019
Obstructive Sleep Apnea: Emerging Treatments Targeting the Genioglossus Muscle.
Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Drug-induced sleep endoscopy in obstructive sleep apnea: a systematic review and meta-analysis of sedative agents, monitoring methods, and administration techniques.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Pooled it
- Uvulopalatopharyngoplasty with and without modified thyrohyoid suspension for obstructive sleep apnea treatment: a randomized clinical trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Trial
- Cephalometric Measurements of Upper Airway at Upright and Supine Posture in Adult OSAS Patients.European journal of dentistry · 2026Article
- KalinixSleep & breathing = Schlaf & Atmung · 2026Article
- Exploring Exercise Interventions for Obstructive Sleep Apnea: A Scoping Review.Journal of functional morphology and kinesiology · 2025Review
- Evaluating the Association Between Risk Factors of Obstructive Sleep Apnea with Oral Dysfunction and Lifestyle Behavior in Korean Adults Using Data from the Eighth Cycle of the National Health and Nutrition Examination Survey: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Validity and reliability of an protocol of the stomatognathic and postural system evaluation for patients with obstructive sleep apnea: a cross-sectional study.Frontiers in physiology · 2025Article
- Dental pulp stem cells promote genioglossus repair and systemic amelioration in chronic intermittent hypoxia.iScience · 2024Article
- Role of Nasal Surgery in Adult Obstructive Sleep Apnea: A Systematic Review.Sleep science (Sao Paulo, Brazil) · 2024Review
- Bioinformatics-based identification of key candidate genes and signaling pathways in patients with Parkinson's disease and obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- A mandibular advancement device associated with lingual control: a new treatment option for obstructive sleep apnea?Sleep & breathing = Schlaf & Atmung · 2024Article
- Predicting OSA Using Radiographs of the Airway Anatomy.Nature and science of sleep · 2024Article
- An exploratory study on the association between serotonin and sleep breathing disorders.Scientific reports · 2023Observational
- Oxytocin mediated excitation of hypoglossal motoneurons: implications for treating obstructive sleep apnea.Sleep · 2023Article
- Observational
- Does Frenotomy Modify Upper Airway Collapse in OSA Adult Patients? Case Report and Systematic Review.Journal of clinical medicine · 2022Article
- OSA: Treatments beyond CPAP.Journal of clinical medicine · 2022Article
- Patient-Centered Therapy for Obstructive Sleep Apnea: A Review.Medicina (Kaunas, Lithuania) · 2022Review
- Effectiveness of a Uniquely Designed Oral Appliance on Obstructive Sleep Apnea Control: A Pilot Study.European journal of dentistry · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive sleep apnea (OSA) is characterized by repetitive episodes of upper airway obstruction caused by a loss of upper airway dilator muscle tone during sleep and an inadequate compensatory response by these muscles in the context of an anatomically compromised airway. The genioglossus (GG) is the main upper airway dilator muscle. Currently, continuous positive airway pressure is the first-line treatment for OSA. Nevertheless, problems related to poor adherence have been described in some groups of patients. In recent years, new OSA treatment strategies have been developed to improve GG function. (A) Hypoglossal nerve electrical stimulation leads to significant improvements in objective (apnea-hypopnea index, or AHI) and subjective measurements of OSA severity, but its invasive nature limits its application. (B) A recently introduced combination of drugs administered orally before bedtime reduces AHI and improves the responsiveness of the GG. (C) Finally, myofunctional therapy also decreases AHI, and it might be considered in combination with other treatments. Our objective is to review these therapies in order to advance current understanding of the prospects for alternative OSA treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.