ReviewJournal of clinical medicine2019
Oral-Gut Microbiota and Arthritis: Is There an Evidence-Based Axis?
Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Correlation between the Altered Gut Microbiome and Lifestyle Interventions in Chronic Widespread Pain Patients: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Targeted Microbial Shifts and Metabolite Profiles Were Associated with Clinical Response to an Anti-Inflammatory Diet in Osteoarthritis.Nutrients · 2025Trial
- The Gut-Bone Axis: A Systematic Review on the Potential Intervention Pathways for Bone Health.Life (Basel, Switzerland) · 2026Review
- Targeting the gut‑bone axis through exercise: A novel approach to osteoporosis prevention and treatment (Review).International journal of molecular medicine · 2026Review
- Analysis of gut microbiota characteristics in osteoarthritis patients.Frontiers in cellular and infection microbiology · 2026Article
- The brain-gut-joint axis in arthritis: crosstalk, treatment, and future perspectives.Journal of orthopaedic translation · 2026Review
- The oral-gut-joint axis in osteoarthritis: a multiomics case-control study.Frontiers in cellular and infection microbiology · 2026Observational
- Causal Relationships Between the Oral Microbiome and Autoimmune Diseases: A Mendelian Randomization Study.Pathogens (Basel, Switzerland) · 2025Article
- Bacterial extracellular vesicles in osteoarthritis: a new bridge of the gut-joint axis.Gut microbes · 2025Review
- Differential Patterns of Gut and Oral Microbiomes in Hispanic Individuals with Cognitive Impairment.Microorganisms · 2025Article
- Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine.Journal of advanced research · 2025Review
- Progress in multi-omics studies of osteoarthritis.Biomarker research · 2025Review
- Integrated oral-gut microbiota therapy: a novel perspective on preventing bacterial translocation for systemic disease management.Frontiers in cellular and infection microbiology · 2025Review
- Investigating the causal impact of gut microbiota on arthritis via inflammatory proteins using mendelian randomization.Scientific reports · 2024Article
- Review
- The Oral Administration ofCurrent issues in molecular biology · 2024Article
- Oral microbiota diversity in moderate to severe plaque psoriasis, nail psoriasis and psoriatic arthritis.Scientific reports · 2024Article
- Periodontal bacteria influence systemic diseases through the gut microbiota.Frontiers in cellular and infection microbiology · 2024Review
- The curious case ofGut microbes · 2023Review
- Impact of humid climate on rheumatoid arthritis faecal microbiome and metabolites.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome appears to be a significant contributor to musculoskeletal health and disease. Recently, it has been found that oral microbiota are involved in arthritis pathogenesis. Microbiome composition and its functional implications have been associated with the prevention of bone loss and/or reducing fracture risk. The link between gut-oral microbiota and joint inflammation in animal models of arthritis has been established, and it is now receiving increasing attention in human studies. Recent papers have demonstrated substantial alterations in the gut and oral microbiota in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). These alterations resemble those established in systemic inflammatory conditions (inflammatory bowel disease, spondyloarthritides, and psoriasis), which include decreased microbial diversity and a disturbance of immunoregulatory properties. An association between abundance of oral
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.