Evidence map›Paper›PMID 31652541›Full record

ArticleBiomolecules2019

CDK12 Activity-Dependent Phosphorylation Events in Human Cells.

Bartlomiej Bartkowiak, Christopher M Yan, Erik J Soderblom, Arno L Greenleaf

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Article
  5. Functional characterization and potential therapeutic avenues for variants in the NTRK2 gene causing developmental and epileptic encephalopathies.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022
    Article
  6. Review
  7. CDK9 keeps RNA polymerase II on track.Cellular and molecular life sciences : CMLS · 2021
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bartlomiej BartkowiakDepartment of Biochemistry, Duke Med. Ctr., Durham, NC 27710, USA. bartjbartkowiak@gmail.com.
Christopher M YanDepartment of Biochemistry, Duke Med. Ctr., Durham, NC 27710, USA. cmartinyan@gmail.com.
Erik J SoderblomProteomics Core Facility, Duke Med. Ctr., Durham, NC 27710, USA. erik.soderblom@duke.edu.
Arno L GreenleafDepartment of Biochemistry, Duke Med. Ctr., Durham, NC 27710, USA. arno@duke.edu.
Duke University · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
NCI NIH HHS P30 CA014236
6 · The paper itself

Abstract

We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12

Indexed as

Cyclin-Dependent KinasesHeLa CellsHumansPeptidesPhosphorylationProtein Kinase InhibitorsCDK12 protein, humanCyclin-Dependent KinasesPeptidesProtein Kinase Inhibitors1-NM-PP1analog-sensitive CTD kinaseCTDmESC undifferentiated statemRNA nuclear exportnuclear poreRNA polymerase IIRNA processingTPRtranscriptionXPC

Identifiers

PMID31652541
PMCPMC6844070
OpenAlexW2982077476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.