Evidence map›Paper›PMID 31652531›Full record

SynthesisInternational journal of molecular sciences2019

The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review.

Simone Perna, Tariq A Alalwan, Zahraa Alaali, Tahera Alnashaba, Clara Gasparri, Vittoria Infantino, Layla Hammad, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini and 1 more

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 177 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
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  6. Article
  7. Article
  8. Alanyl-Glutamine Dipeptide MitigatesInternational journal of molecular sciences · 2026
    Article
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  10. Review
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  13. Review
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  17. Inhibition of microglial glutaminase alleviates chronic stress-induced neurobehavioral and cognitive deficits.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Simone PernaDepartment of Biology, College of Science, University of Bahrain, 32038 Sakhir, Bahrain. sperna@uob.edu.bh.ORCID 0000-0002-2720-1473
Tariq A AlalwanDepartment of Biology, College of Science, University of Bahrain, 32038 Sakhir, Bahrain. talalwan@uob.edu.bh.ORCID 0000-0002-7693-4542
Zahraa AlaaliDepartment of Biology, College of Science, University of Bahrain, 32038 Sakhir, Bahrain. zahraaj.alaali@gmail.com.ORCID 0000-0002-0022-9919
Tahera AlnashabaDepartment of Biology, College of Science, University of Bahrain, 32038 Sakhir, Bahrain. tahera.alnashaba@gmail.com.
Clara GasparriEndocrinology and Nutrition Unit, Azienda di Servizi alla Persona ''Istituto Santa Margherita'', University of Pavia, Pavia 27100, Italy. gasparri.clara@gmail.com.
Vittoria InfantinoDepartment of Biomedical Science and Human Oncology, University of Bari, Bari 70121, Italy. viriainfantino@hotmail.it.ORCID 0000-0001-8172-5182
Layla HammadDepartment of Biology, College of Science, University of Bahrain, 32038 Sakhir, Bahrain. Laylabh2018@outlook.com.
Antonella RivaResearch and Development Department, Indena SpA, 20139 Milan, Italy. Antonella.riva@indena.com.
Giovanna PetrangoliniResearch and Development Department, Indena SpA, 20139 Milan, Italy. Giovanna.petrangolini@indena.com.ORCID 0000-0001-6681-7329
Pietro AllegriniResearch and Development Department, Indena SpA, 20139 Milan, Italy. Pietro.allegrini@indena.com.
Mariangela RondanelliIRCCS Mondino Foundation, Pavia 27100, Italy. mariangela.rondanelli@unipv.it.ORCID 0000-0001-8336-4851
University of Bahrain · BHIndena (Italy) · ITUniversity of Pavia · ITUniversity of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The scientific literature has demonstrated that glutamine is one of the main beneficial amino acids. It plays an important role in gut microbiota and immunity. This paper provides a critical overview of experimental studies (in vitro, in vivo, and clinical) investigating the efficacy of glutamine and its effect on gut microbiota. As a result of this review, we have summarized that glutamine could affect gut microbiota via different mechanisms including the reduction in the ratio of

Indexed as

Gastrointestinal MicrobiomeAnimalsDietGlutamineHumansNutrition DisordersGlutamineamino acidsdietglutamateglutaminegutmicrobiomemicrobiotaobesity

Identifiers

PMID31652531
PMCPMC6834172
OpenAlexW2981670075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.