ArticleInternational journal of molecular sciences2019
The Mechanisms Underlying the Cytotoxic Effects of Copper Via Differentiated Embryonic Chondrocyte Gene 1.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Activated Carbon Fiber Incorporated with Metal Ions: Characterization and Biological Interactions In Vitro.International journal of molecular sciences · 2026Article
- Differential cytotoxicity mechanisms of copper complexed with disulfiram for combination chemotherapy in human endometrial cancer cells.Frontiers in oncology · 2026Article
- Antibacterial, Redox, Cytotoxic, and Ecotoxic Properties of New Sol-Gel Silica-Copper-Based Materials.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Autofluorescence Quenching in Decellularized Plant Scaffolds for Tissue Engineering.Annals of biomedical engineering · 2025Article
- Article
- Virucidal Efficacy of Laser-Generated Copper Nanoparticle Coatings against Model Coronavirus and Herpesvirus.ACS applied materials & interfaces · 2025Article
- Article
- Novel Treatment for a Giant Acrochordon Using Pachaieruvai, a Traditional Siddha Medicine: A Case Report.Cureus · 2025Article
- Nitric Oxide Activatable Photodynamic Therapy Agents Based on BODIPY-Copper Complexes.ACS pharmacology & translational science · 2025Article
- Article
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- Overcoming Giant Verruca Vulgaris Treatment Obstacles With Siddha Medicine: A Case Report.Cureus · 2024Article
- Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers.Nature communications · 2024Article
- Easy Access to Bright Oxygen Defects in Biocompatible Single-Walled Carbon Nanotubes via a Fenton-like Reaction.ACS nano · 2024Article
- Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells.Scientific reports · 2024Article
- Article
- Keratin/Copper Complex Electrospun Nanofibers for Antibacterial Treatments: Property Investigation and In Vitro Response.Materials (Basel, Switzerland) · 2024Article
- Article
- Among Gerontogens, Heavy Metals Are a Class of Their Own: A Review of the Evidence for Cellular Senescence.Brain sciences · 2023Review
- Copper in cancer: from limiting nutrient to therapeutic target.Frontiers in oncology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Copper is an essential trace element within cells, but it also exerts cytotoxic effects through induction of reactive oxygen species (ROS) production. To determine the mechanisms underlying copper-induced ROS production, we examined the effects of copper sulfate in HeLa cells. Exposure to copper sulfate led to dose-dependent decreases in HeLa cell viability, along with increases in the subG1 and G2/M populations and corresponding decreases in the G1 population. Copper sulfate also increased the levels of apoptosis, senescence, mitochondrial dysfunction, autophagy, ROS, and the expression of several stress proteins, including ATF3, c-Fos, DEC1 (differentiated embryonic chondrocyte gene 1), p21, p53, and HIF-1α (hypoxia-inducible factor 1 alpha). The suppression of copper-induced ROS generation by the ROS scavenger
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.