Evidence map›Paper›PMID 31652489›Full record

ReviewMarine drugs2019

Research Progress in the Biosynthetic Mechanisms of Marine Polyether Toxins.

Xiukun Wan, Ge Yao, Yanli Liu, Jisheng Chen, Hui Jiang

Abstract readReview
In one paragraph

Review in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Bioactive Polyketides fromMarine drugs · 2025
    Review
  2. Review
  3. Review
  4. Review
  5. Gambierol Blocks a KToxins · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiukun WanState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China. xiukunwan@126.com.ORCID 0000-0001-8309-250X
Ge YaoState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China. bzyaoge@163.com.
Yanli LiuState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China. liuh306@hotmail.com.
Jisheng ChenState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China. chenjsh@cae.cn.
Hui JiangState Key Laboratory of NBC Protection for Civilian, Beijing 102205, China. jiangtide@sina.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine polyether toxins, mainly produced by marine dinoflagellates, are novel, complex, and diverse natural products with extensive toxicological and pharmacological effects. Owing to their harmful effects during outbreaks of marine red tides, as well as their potential value for the development of new drugs, marine polyether toxins have been extensively studied, in terms of toxicology, pharmacology, detection, and analysis, structural identification, as well as their biosynthetic mechanisms. Although the biosynthetic mechanisms of marine polyether toxins are still unclear, certain progress has been made. In this review, research progress and current knowledge on the biosynthetic mechanisms of polyether toxins are summarized, including the mechanisms of carbon skeleton deletion, pendant alkylation, and polyether ring formation, along with providing a summary of mined biosynthesis-related genes. Finally, future research directions and applications of marine polyether toxins are discussed.

Indexed as

AlkylationAnti-Bacterial AgentsAquatic OrganismsBiosynthetic PathwaysComputational BiologyDinoflagellidaEthersMarine ToxinsAnti-Bacterial AgentsEthersMarine Toxinsbiosynthesis-related genesbiosynthetic mechanismscarbon skeleton deletionmarine polyether toxinspendant alkylationpolyether ring formation

Identifiers

PMID31652489
PMCPMC6835853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.