ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Dissociable roles for the ventral and dorsal medial prefrontal cortex in cue-guided risk/reward decision making.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 65 citations in OpenAlex.
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- Complementary yet Dissociable Influences of Medial and Lateral Orbitofrontal Cortex over Cue-Guided Decisions Involving Reward Magnitude and Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Impact of the Traditional Lecture Teaching Method and Dalcroze's Body Rhythmic Teaching Method on the Teaching of Emotion in Music-A Cognitive Neuroscience Approach.Brain sciences · 2025Article
- Prefrontal Oxygenation in a Subjective Decision on a Situational Danger Assessment Task: Personality Traits and Decision-Making Styles Involvement.Behavioral sciences (Basel, Switzerland) · 2025Article
- The infralimbic, but not the prelimbic cortex is needed for a complex olfactory memory task.Neurobiology of learning and memory · 2025Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.Science advances · 2025Article
- A distinct hypothalamus-habenula circuit governs risk preference.Nature neuroscience · 2025Article
- The Infralimbic, but not the Prelimbic Cortex is needed for a Complex Olfactory Memory Task.bioRxiv : the preprint server for biology · 2024Article
- Dissociable Roles of the mPFC-to-VTA Pathway in the Control of Impulsive Action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats.The international journal of neuropsychopharmacology · 2024Article
- Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.bioRxiv : the preprint server for biology · 2024Article
- Medial prefrontal cortex suppresses reward-seeking behavior with risk of punishment by reducing sensitivity to reward.Frontiers in neuroscience · 2024Article
- The rat frontal orienting field dynamically encodes value for economic decisions under risk.Nature neuroscience · 2023Article
- Neural circuits controlling choice behavior in opioid addiction.Neuropharmacology · 2023Review
- Temporal Dynamics Underlying Prelimbic Prefrontal Cortical Regulation of Action Selection and Outcome Evaluation during Risk/Reward Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Prelimbic cortex neural encoding dynamically tracks expected outcome value.Physiology & behavior · 2022Article
- Estrus cycle-dependent working memory effects of prefrontal cortex corticotropin-releasing factor neurotransmission.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Behavior of Rats in a Self-Paced Risky Decision-Making Task Based on Definite Probability.Brain sciences · 2022Article
- PKCδ-positive GABAergic neurons in the central amygdala exhibit tissue-type plasminogen activator: role in the control of anxiety.Molecular psychiatry · 2022Article
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2 authors at 2 institutions in 1 country.
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Abstract
Converging evidence from studies with animals and humans have implicated separate regions of the medial prefrontal cortex (mPFC) corresponding to the anterior cingulate cortex (ACC), in mediating different aspects of reward-related decisions involving uncertainty or risk. However, the dissociable contributions of subregions of the ACC remain unclear, as discrepancies exist between human neuroimaging findings and preclinical rodent studies. To clarify how ventral vs. dorsal regions of the mPFC contribute to risk/reward decision making, the present study assessed the effects of inactivation of different subregions on performance of a "Blackjack task" that measured cue-guided decision making and shares similarities with paradigms used with humans. Male, Long-Evans rats were well-trained to choose between a Small/Certain reward vs a Large/Risky reward delivered with variable probabilities (i.e., good vs. poor-odds, 50% vs. 12.5%). The odds of obtaining the larger reward was signaled by auditory cues at the start of each trial. Inactivation of the ventral, infralimbic region of the mPFC increased risky choice selectively when the odds of winning were poor. By contrast, inactivation of the prelimbic and anterior cingulate regions of the dorsal mPFC led to suboptimal reductions in risky choice on good-odds trials. The effects of prelimbic vs anterior cingulate inactivations were associated with context-dependent alterations in reward vs negative feedback, respectively. These results further clarify the distinct yet complementary manners in which separate ACC regions promote optimal risk/reward decision making and complement neuroimaging findings that activity in human ventral vs dorsal ACC promotes risk aversion or risky choices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.