Evidence map›Paper›PMID 31652414›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Epigenetic regulation of TIMP1 expression by 8-oxoguanine DNA glycosylase-1 binding to DNA:RNA hybrid.

Lang Pan, Hui Wang, Jinhua Luo, Ji Zeng, Jiao Pi, Huijun Liu, Chi Liu, Xueqing Ba, Xiangping Qu, Yang Xiang and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. 8-Oxoguanine: A Lesion, an Epigenetic Mark, or a Molecular Signal?International journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. OGG1 in Lung-More than Base Excision Repair.Antioxidants (Basel, Switzerland) · 2022
    Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Lang PanDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Hui WangDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Jinhua LuoDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Ji ZengDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Jiao PiDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Huijun LiuDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Chi LiuDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Xueqing BaThe Key Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, China.
Xiangping QuDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Yang XiangDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Istvan BoldoghDepartment of Microbiology and Immunology, School of Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Xiaoqun QinDepartment of Physiology, School of Basic Medicine, Xiangya Medical School, Central South University, Changsha, China.
Central South University · CNNortheast Normal University · CNThe University of Texas Medical Branch at Galveston · US

Funding

Virus, Tissue Culture and ImmunoassayP01AI062885 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CASOLA, ANTONELLA · 2005 to 2022
$23.9M
NIAID NIH HHS P01 AI062885
6 · The paper itself

Abstract

8-Oxoguanine DNA glycosylase-1 (OGG1)-initiated base excision repair pathway is primarily responsible for 7, 8-dihydro-8-oxoguanine (8-oxoG) removal from DNA. Recent studies, however, have shown that 8-oxoG in gene regulatory elements may serve as an epigenetic mark, and OGG1 has distinct functions in modulating gene expression. Genome-wide mapping of oxidative stress-induced OGG1 enrichment within introns was documented, but its significance has not yet been fully characterized. Here, we explored whether OGG1 recruited to intron 1 of tissue inhibitor of metalloproteinase-1 (TIMP1) gene and modulated its expression. Using chromatin and DNA:RNA hybrid immunoprecipitation assays, we report recruitment of OGG1 to the DNA:RNA hybrid in intron 1, where it increases nascent RNA but lowers mRNA levels in O

Indexed as

Epigenesis, GeneticAnimalsBronchiCell LineDNA GlycosylasesDNA ProbesEpithelial CellsGene Expression RegulationHumansImmunoprecipitationMaleMiceMice, Inbred C57BLOzoneRespiratory MucosaTissue Inhibitor of Metalloproteinase-1DNA GlycosylasesDNA ProbesOgg1 protein, mouseoxoguanine glycosylase 1, humanOzoneTIMP1 protein, humanTimp1 protein, mouseTissue Inhibitor of Metalloproteinase-1DNA damage and repairoxidative stresstranscriptional modulation

Identifiers

PMID31652414
PMCPMC6894084
OpenAlexW2982274199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.