ArticleBritish journal of clinical pharmacology2020
Misuse of benzodiazepines: Prevalence and impact in an inpatient population with psychiatric disorders.
Article in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Chronic Chrysin, but Not Diazepam, Induces Anxiolytic-like Effects Without Behavioral Tolerance.Molecules (Basel, Switzerland) · 2026Article
- Synergistic Effect ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Benzodiazepines Prescribed to Hospitalized Patients with Major Depressive Disorder: A 3-year Retrospective Observational Study.Neuropsychiatric disease and treatment · 2026Article
- Benzodiazepines and Opioid co-use Among Rural People Who Use Drugs: Findings From the Rural Opioid Initiative.Substance use & addiction journal · 2025Article
- Psychiatric and racial/ethnic differences in incident and long-term benzodiazepine use: A commercial healthcare claims study.Journal of psychiatric research · 2025Article
- Benzodiazepine use in medical cannabis authorization adult patients from 2013 to 2021: Alberta, Canada.BMC public health · 2024Article
- Article
- [Factors associated with benzodiazepines dependence in insomnia patients].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
- Add-On Treatment withPharmaceuticals (Basel, Switzerland) · 2023Article
- A Lupin (International journal of molecular sciences · 2022Article
- Prevalence and Correlates of Prescription Drug Misuse in a Nationwide Population Survey in Taiwan.International journal of environmental research and public health · 2021Article
- Misuse of benzodiazepines: Prevalence and impact in an inpatient population with psychiatric disorders.British journal of clinical pharmacology · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsUse and misuse of benzodiazepine might be very prevalent in patients with acute psychiatric symptoms, whereas they might be associated with specific adverse events in this population. The study investigated their prevalence in these patients. Secondary objectives were to identify risk factors for misuse of benzodiazepines, and its impact.
methodsA cohort study was based on the hospital's electronic patient records and conducted in patients aged 18 years and over and admitted to a psychiatric hospital. They were followed up for 84 days or until the end of hospitalisation. Four variables of misuse were built: excessive duration of treatment, type of product, excessive dosage and concomitant benzodiazepines. Backward stepwise multivariate logistic regression analysis was used to assess risk factors for each misuse criterion, on the 1 hand, and impact of benzodiazepine misuse, on the other.
resultsIn total, 511 psychiatric inpatients were included with 89.0% of them exposed to benzodiazepine. Discharge prescription included no benzodiazepine or a dosage lower than the maximum dosage prescribed during hospitalisation for 78.2% of patients exposed to benzodiazepine during their stay. Of benzodiazepine treatments, 31.4% were associated with at least 1 misuse criterion. Excessive dosage was associated with age ≥65 years (OR 11.57; 95% confidence interval 4.92-27.17), substance/alcohol use disorders (3.35; 95% confidence interval 1.70-6.62) and parenthood (0.49; 0.25-0.97). Some criteria of benzodiazepine misuse were associated with a higher frequency of adverse events occurring after treatment initiation.
conclusionsMisuse of benzodiazepines is very common in inpatients with psychiatric disorders. These findings should alert clinicians to comply with clinical recommendations.
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