Evidence map›Paper›PMID 31652316›Full record

ReviewEssays in biochemistry2019

Establishment, maintenance, and biological roles of non-CG methylation in plants.

Sunil K Kenchanmane Raju, Eleanore Jeanne Ritter, Chad E Niederhuth

Abstract readReview
In one paragraph

Review in Essays in biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
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  3. Omics landscapes in molecular mechanisms withFood chemistry. Molecular sciences · 2025
    Review
  4. Epigenomes · 2025
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sunil K Kenchanmane RajuDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824, U.S.A.
Eleanore Jeanne RitterDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824, U.S.A.
Chad E NiederhuthDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824, U.S.A.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytosine DNA methylation is prevalent throughout eukaryotes and prokaryotes. While most commonly thought of as being localized to dinucleotide CpG sites, non-CG sites can also be modified. Such non-CG methylation is widespread in plants, occurring at trinucleotide CHG and CHH (H = A, T, or C) sequence contexts. The prevalence of non-CG methylation in plants is due to the plant-specific CHROMOMETHYLASE (CMT) and RNA-directed DNA Methylation (RdDM) pathways. These pathways have evolved through multiple rounds of gene duplication and gene loss, generating epigenomic variation both within and between species. They regulate both transposable elements and genes, ensure genome integrity, and ultimately influence development and environmental responses. In these capacities, non-CG methylation influence and shape plant genomes.

Indexed as

DNADNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Transposable ElementsGene Expression Regulation, PlantPlant Physiological PhenomenaPlant ProteinsPlantsReproductionStress, PhysiologicalchromomethylaseDNADNA (Cytosine-5-)-MethyltransferasesDNA Transposable ElementsPlant Proteinschromatinepigeneticsepigenomicsmethylationplant biology

Identifiers

PMID31652316
PMCPMC6923318

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.