ArticleThe Biochemical journal2019
The chromogranin A-derived antifungal peptide CGA-N9 induces apoptosis in Candida tropicalis.
Article in The Biochemical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Antifungal activity of volatile organic compounds produced byFrontiers in microbiology · 2026Article
- A promising antifungal lipopeptide from Bacillus subtilis: its characterization and insight into the mode of action.Applied microbiology and biotechnology · 2024Article
- Antifungal peptides from living organisms.Frontiers in microbiology · 2024Review
- Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically ImportantPharmaceutics · 2023Review
- The elucidation of the multimodal action of the investigational anti-Frontiers in molecular biosciences · 2023Article
- Cecropin D-derived synthetic peptides in the fight againstFrontiers in microbiology · 2022Article
- Ethanolic extract ofFrontiers in cellular and infection microbiology · 2022Article
- TheJournal of fungi (Basel, Switzerland) · 2020Article
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Authors and funding
9 authors.
Funding
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Abstract
CGA-N9, a peptide derived from human chromogranin A (CGA), was found to have antimicrobial activity in our previous investigation, but its mechanism of action remains unclear. Herein, the mechanism of action of CGA-N9 was investigated. We found that CGA-N9 induced the depolarization of the cell membrane and uptake of calcium ions into the cytosol and mitochondria. With the disruption of the mitochondrial membrane potential, the generation of intracellular reactive oxygen species (ROS) increased. Accordingly, we assessed apoptotic processes in Candida tropicalis cells post-treatment with CGA-N9 and found cytochrome c leakage, chromatin condensation and DNA degradation. The interaction of CGA-N9 with DNA in vitro showed that CGA-N9 did not degrade DNA but bound to DNA via an electrostatic interaction. In conclusion, CGA-N9 exhibits antifungal activity by inducing apoptosis in C. tropicalis.
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