ArticleMedicine and science in sports and exercise2020
Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation.
Article in Medicine and science in sports and exercise, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Combinations of Physical Activity, Sedentary Behavior, and Sleep Duration and Their Associations With Physical, Psychological, and Educational Outcomes in Children and Adolescents: A Systematic Review.American journal of epidemiology · 2023Pooled it
- Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review.Frontiers in pediatrics · 2022Pooled it
- Review
- The Impact of Physical Exercise on Male Fertility Through Its Association with Various Processes and Aspects of Human Biology.Journal of clinical medicine · 2025Review
- Data Analytics in Physical Activity Studies With Accelerometers: Scoping Review.Journal of medical Internet research · 2024Article
- Mediation effect of JAK2 methylation on the association between sitting time and abdominal obesity in rural adults.European journal of clinical nutrition · 2023Article
- Cross-sectional associations between phthalates, phenols, and parabens with metabolic syndrome risk during early-to-mid adolescence among a cohort of Mexican youth.Environmental research · 2023Article
- Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems.Clinical epigenetics · 2023Review
- Is adiposity related to repeat measures of blood leukocyte DNA methylation across childhood and adolescence?Clinical obesity · 2023Article
- Urinary phthalates, phenols, and parabens in relation to sleep health markers among a cohort of Mexican adolescents.The Science of the total environment · 2023Article
- DNA Methylation Is a Potential Biomarker for Cardiometabolic Health in Mexican Children and Adolescents.Epigenomes · 2023Article
- Epigenetic regulation of Parkinson's disease risk variant GPNMB cg17274742 methylation by sex and exercise from Taiwan Biobank.Frontiers in aging neuroscience · 2023Article
- Dose-response association between 24-hour total movement activity and testosterone deficiency in adult males.Frontiers in endocrinology · 2023Article
- Sedentary patterns and cardiometabolic risk factors in Mexican children and adolescents: analysis of longitudinal data.The international journal of behavioral nutrition and physical activity · 2022Article
- Diet Quality Scores and Cardiometabolic Risk Factors in Mexican Children and Adolescents: A Longitudinal Analysis.Nutrients · 2022Article
- Adolescent sleep timing and dietary patterns in relation to DNA methylation of core circadian genes: a pilot study of Mexican youth.Epigenetics · 2021Article
- Dietary Patterns in Relation to Prospective Sleep Duration and Timing among Mexico City Adolescents.Nutrients · 2020Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
introduction/purposeLimited studies have examined the association of physical activity with reproductive hormones, DNA methylation, and pubertal status among adolescents.
methodsAmong 248 boys and 271 girls, we estimated daily physical activity levels based on 7 d of wrist-worn accelerometer data. We used an isotemporal substitution paradigm and sex-stratified regression models to examine the association of physical activity levels with 1) testosterone, cortisol, progesterone, and androstenedione concentrations; 2) DNA methylation of long interspersed nucleotide (LINE-1) repeats and the genes H19, hydroxysteroid (11-Beta) dehydrogenase 2 (HSD11B2), and peroxisome proliferator-activated receptor alpha (PPARA) from blood leukocytes; and 3) Tanner stages, adjusted for age, BMI, and socioeconomic status.
resultsIn boys, substituting 30 min of moderate physical activity for 30 min of sedentary behavior per day was associated with 29% (-49%, 0%) of lower testosterone and 29% (4%, 61%) of higher progesterone. Substituting 30 min of light physical activity for sedentary behavior was associated with 13% (-22%, -2%) of lower progesterone. Among girls, 30 min of additional sedentary behavior was associated with 8% (-15%, 0%) of lower testosterone and 24% (8%, 42%) of higher progesterone concentrations. Substituting 30 min of moderate physical activity for sedentary behavior was associated with 15% (0%, 31%) of higher cortisol, whereas substituting the same amount of light physical activity for sedentary behavior was associated with 22% (-39%, 0%) of lower progesterone. Substituting 30 min of vigorous physical activity for sedentary behavior per day was associated with almost six times higher levels (5.83, 95% confidence interval = 1.79-9.86) of HSD11B2 methylation in boys.
conclusionsAccelerometer-measured daily physical activity was associated with reproductive hormones and HSD11B2 DNA methylation, differed by sex and activity intensity levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.