Evidence map›Paper›PMID 31652121›Full record

ReviewRadiology and oncology2019

Advances in the management of craniopharyngioma in children and adults.

Mojca Jensterle, Soncka Jazbinsek, Roman Bosnjak, Mara Popovic, Lorna Zadravec Zaletel, Tina Vipotnik Vesnaver, Barbara Faganel Kotnik, Primoz Kotnik

Open access · goldAbstract readReview
In one paragraph

Review in Radiology and oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Endoscopic endonasal versus open approach for craniopharyngioma treatment: a systematic review of clinical characteristics.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Mapping influence in pediatric craniopharyngioma: the 50 most cited articles.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Limitations of MRI in differentiating solid and cystic components of craniopharyngiomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  12. Effects of Timing it Right Brain Tumor Support Program (TIRBTSP) on clinical outcome for patients diagnosed with sellar region tumors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  13. Article
  14. Histiocytic sarcoma of the suprasellar region: illustrative case.Journal of neurosurgery. Case lessons · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mojca JensterleDepartment of Endocrinology, Diabetes and Metabolism, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Soncka JazbinsekMedical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Roman BosnjakMedical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Mara PopovicMedical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Lorna Zadravec ZaletelMedical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Tina Vipotnik VesnaverMedical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Barbara Faganel KotnikMedical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Primoz KotnikMedical Faculty, University of Ljubljana, Ljubljana, Slovenia.
University of Ljubljana · SILjubljana University Medical Centre · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of the sellar, suprasellar, and parasellar region. Survival rates are high; however, tumor location and treatment sequalae including endocrine deficits, visual impairment, metabolic complications, cognitive and psychosocial deficits can significantly impair patient's quality of life. There is considerable controversy regarding the optimal management of craniopharyngiomas. Subtotal resection of the tumor followed by targeted irradiation to avoid further hypothalamic damage is currently indicated. Novel insights in the tumor's molecular pathology present the possibility for targeted therapy possibly decreasing the rate and severity of treatment-associated morbidity. Conclusions Craniopharyngioma should be seen as a chronic disease. To achieve optimal outcomes a multidisciplinary team of specialized neurosurgeons, neuro-radiologists, neuro-oncologists, pathologists and endocrinologists should be involved in the diagnosis, planning of the surgery, irradiation and long-term follow-up.

Indexed as

Magnetic Resonance ImagingTomography, X-Ray ComputedAdultAge of OnsetChildCraniopharyngiomaDisease ProgressionHumansHypothalamic DiseasesHypothalamusNeoplasm GradingObesityPituitary NeoplasmsPrognosisQuality of LifeRadiosurgerycraniopharyngiomaCTNNB1 genehypopituitarismMAPK/ERK pathwaymetabolic syndromeproton beam therapy

Identifiers

PMID31652121
PMCPMC6884937
OpenAlexW2981975691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.