ArticleHuman brain mapping2020
Longitudinal stability of the brain functional connectome is associated with episodic memory performance in aging.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Oxygen: The Rate-Limiting Factor for Episodic Memory Performance, Even in Healthy Young Individuals.Biomolecules · 2020Trial
- Functional-structural co-dependent brain mapping of metamemory in amnestic mild cognitive impairment.Alzheimer's research & therapy · 2025Article
- The Effect of Sleep Deprivation on Brain Fingerprint Stability: A Magnetoencephalography Validation Study.Sensors (Basel, Switzerland) · 2024Article
- Childhood Disadvantage Moderates Late Midlife Default Mode Network Cortical Microstructure and Visual Memory Association.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2023Article
- A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Functional connectome fingerprinting across the lifespan.Network neuroscience (Cambridge, Mass.) · 2023Article
- The confound of head position in within-session connectome fingerprinting in infants.NeuroImage · 2023Article
- Intra and inter-individual variability in functional connectomes of patients with First Episode of Psychosis.NeuroImage. Clinical · 2023Article
- The effects of age on category learning and prototype- and exemplar-based generalization.Psychology and aging · 2022Article
- Dynamic trajectories of connectome state transitions are heritable.NeuroImage · 2022Article
- Evaluation of functional MRI-based human brain parcellation: a review.Journal of neurophysiology · 2022Review
- Changes in pairwise functional connectivity associated with changes in cognitive performance in cognitively normal older individuals: A two-year observational study.Neuroscience letters · 2022Observational
- Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go?Biological psychiatry · 2022Review
- Functional Connectome Dynamics After Mild Traumatic Brain Injury According to Age and Sex.Frontiers in aging neuroscience · 2022Article
- Research trends and hotspots on connectomes from 2005 to 2021: A bibliometric and latent Dirichlet allocation application study.Frontiers in neuroscience · 2022Article
- Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults.Frontiers in aging neuroscience · 2021Article
- Longitudinal stability of medial temporal lobe connectivity is associated with tau-related memory decline.eLife · 2020Article
- Causality-Based Feature Fusion for Brain Neuro-Developmental Analysis.IEEE transactions on medical imaging · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain functional connectome forms a relatively stable and idiosyncratic backbone that can be used for identification or "fingerprinting" of individuals with a high level of accuracy. While previous cross-sectional evidence has demonstrated increased stability and distinctiveness of the brain connectome during the course of childhood and adolescence, less is known regarding the longitudinal stability in middle and older age. Here, we collected structural and resting-state functional MRI data at two time points separated by 2-3 years in 75 middle-aged and older adults (age 49-80, SD = 6.91 years) which allowed us to assess the long-term stability of the functional connectome. We show that the connectome backbone generally remains stable over a 2-3 years period in middle and older age. Independent of age, cortical volume was associated with the connectome stability of several canonical resting-state networks, suggesting that the connectome backbone relates to structural properties of the cortex. Moreover, the individual longitudinal stability of subcortical and default mode networks was associated with individual differences in cross-sectional and longitudinal measures of episodic memory performance, providing new evidence for the importance of these networks in maintaining mnemonic processing in middle and old age. Together, the findings encourage the use of within-subject connectome stability analyses for understanding individual differences in brain function and cognition in aging.
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