ArticleMedicine2019
Relationship between anemia, serum bilirubin concentrations, and diabetic retinopathy in individuals with type 2 diabetes.
Article in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Role of systemic hypoxia in the progression of diabetic retinopathy: a propensity-matched retrospective cohort study.BMJ open ophthalmology · 2026Article
- Risk Factors for Diabetic Retinopathy Change With Diabetes Duration: Synergistic Effect of Long Duration and Anemia.Journal of diabetes research · 2026Article
- Predicting sight-threatening diabetic retinopathy using the combination of serum cystatin C and indirect bilirubin.Frontiers in endocrinology · 2026Article
- Dietary iron intake is nonlinearly associated with the risk of diabetic retinopathy in adults with type 2 diabetes.BMC endocrine disorders · 2025Article
- Red blood cell count and its inverse association with diabetic retinopathy: Exploratory development of a risk assessment model in a retrospective cohort.Frontiers in endocrinology · 2025Article
- Interplay between Senescence and Macrophages in Diabetic Cardiomyopathy: A Review of the Potential Role of GDF-15 and Klotho.Biomedicines · 2024Review
- Relationship between Biochemical Pathways and Non-Coding RNAs Involved in the Progression of Diabetic Retinopathy.Journal of clinical medicine · 2024Review
- Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy.Frontiers in endocrinology · 2024Review
- Prevalence of anemia and associated All-Cause mortality among adults with Diabetes: The role of chronic kidney disease.Diabetes research and clinical practice · 2023Article
- Deep learning-based fundus image analysis for cardiovascular disease: a review.Therapeutic advances in chronic disease · 2023Review
- Global Prevalence of Anemia Among Type 2 Diabetic Adult Patients: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Acute and Subchronic Toxicity Assessment of Conventional SoxhletJournal of toxicology · 2023Article
- Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.Disease models & mechanisms · 2022Article
- Toxicity evaluation induced by single and 28-days repeated exposure of withametelin and daturaolone in Sprague Dawley rats.Frontiers in pharmacology · 2022Article
- A randomized controlled trial protocol of the cardiovascular safety and efficacy of liraglutide in the treatment of type 2 diabetes.Medicine · 2021Article
- A Clinical Epidemiological Analysis of Prognostic Nutritional Index Associated with Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Early-onset type 2 diabetes: A high-risk factor for proliferative diabetic retinopathy (PDR) in patients with microalbuminuria.Medicine · 2020Observational
- Influencing factors for peripheral and posterior lesions in mild non-proliferative diabetic retinopathy-the Kailuan Eye Study.International journal of ophthalmology · 2020Article
- Total Bilirubin Predicts Severe Progression of Diabetic Retinopathy and the Possible Causal Mechanism.Journal of diabetes research · 2020Article
- Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history.Diabetology & metabolic syndrome · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study sought to assess the hypothesis that anemia is associated with diabetic retinopathy in type 2 diabetes mellitus (DM) and investigate the factors mediating the relationship between anemia and diabetic retinopathy.In total, 1637 individuals with type 2 DM were examined in a cross-sectional study. Anemia was defined as hemoglobin level <120 g/L in women and <130 g/L in men. A logistic regression model was used to determine the association between anemia and diabetic retinopathy.Anemia was more prevalent in individuals with diabetic retinopathy. Logistic regression analysis found a statistically significant association between anemia and diabetic retinopathy after adjustment for traditional risk factors (odds ratio, 1.44; 95% confidence interval, 1.10-1.89, P = .009). Further adjustment for serum bilirubin levels removed the statistically significant association.In individuals with type 2 DM, anemia is related to diabetic retinopathy, and its association may be mediated by a correlated change in serum bilirubin levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.