Evidence map›Paper›PMID 31651666›Full record

ArticleJournal of pediatric gastroenterology and nutrition2020

Community Socioeconomic Deprivation and Nonalcoholic Fatty Liver Disease Severity.

Sarah Orkin, Cole Brokamp, Toshifumi Yodoshi, Andrew T Trout, Chunyan Liu, Syeda Meryum, Stuart Taylor, Christopher Wolfe, Rachel Sheridan, Aradhna Seth and 8 more

Abstract read
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Socioeconomic Factors and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Review
  3. Review
  4. MASLD In Children - A Distinct Phenotype?Current obesity reports · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Food inequity and insecurity and MASLD: burden, challenges, and interventions.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sarah OrkinDivision of Gastroenterology, Hepatology and Nutrition.
Cole BrokampDivision of Biostatistics and Epidemiology.
Toshifumi YodoshiDivision of Gastroenterology, Hepatology and Nutrition.
Andrew T TroutDepartment of Radiology.
Chunyan LiuDivision of Biostatistics and Epidemiology.
Syeda MeryumDivision of Gastroenterology, Hepatology and Nutrition.
Stuart TaylorJames M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center.
Christopher WolfeDivision of Biostatistics and Epidemiology.
Rachel SheridanDepartment of Pathology, Dayton Children's Hospital.
Aradhna SethDivision of Digestive Diseases, University of Cincinnati.
Mohammad Alfrad Nobel BhuiyanDivision of Biostatistics and Epidemiology.
Sanita LeyDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
Ana Catalina Arce-ClacharDivision of Gastroenterology, Hepatology and Nutrition.
Kristin BramlageDivision of Gastroenterology, Hepatology and Nutrition.
Robert KahnDivision of General and Community Pediatrics.
Stavra XanthakosDivision of Gastroenterology, Hepatology and Nutrition.
Andrew F BeckJames M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center.
Marialena MouzakiDivision of Gastroenterology, Hepatology and Nutrition.

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
PEDIATRIC GASTROENTEROLOGY AND NUTRITION TRAINING GRANTT32DK007727 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Phillip P Minar · 1995 to 2026
$11.3M
NIDDK NIH HHS P30 DK078392NIDDK NIH HHS T32 DK007727
6 · The paper itself

Abstract

BACKGROUND AND

objectivesNonalcoholic fatty liver disease (NAFLD) is linked to obesity. Obesity is associated with lower socioeconomic status (SES). An independent link between pediatric NAFLD and SES has not been elucidated. The objective of this study was to evaluate the distribution of socioeconomic deprivation, measured using an area-level proxy, in pediatric patients with known NAFLD and to determine whether deprivation is associated with liver disease severity.

methodsRetrospective study of patients <21 years with NAFLD, followed from 2009 to 2018. The patients' addresses were mapped to census tracts, which were then linked to the community deprivation index (CDI; range 0--1, higher values indicating higher deprivation, calculated from six SES-related variables available publicly in US Census databases).

resultsTwo cohorts were evaluated; 1 with MRI (magnetic resonance imaging) and/or MRE (magnetic resonance elastography) findings indicative of NAFLD (n = 334), and another with biopsy-confirmed NAFLD (n = 245). In the MRI and histology cohorts, the majority were boys (66%), non-Hispanic (77%-78%), severely obese (79%-80%), and publicly insured (55%-56%, respectively). The median CDI for both groups was 0.36 (range 0.15-0.85). In both cohorts, patients living above the median CDI were more likely to be younger at initial presentation, time of MRI, and time of liver biopsy. MRI-measured fat fraction and liver stiffness, as well as histologic characteristics were not different between the high- and low-deprivation groups.

conclusionsChildren with NAFLD were found across the spectrum of deprivation. Although children from more deprived neighborhoods present at a younger age, they exhibit the same degree of NAFLD severity as their peers from less deprived areas.

Indexed as

Elasticity Imaging TechniquesNon-alcoholic Fatty Liver DiseaseChildFemaleHumansLiverMagnetic Resonance ImagingMaleRetrospective StudiesSocioeconomic Factors

Identifiers

PMID31651666
PMCPMC8054652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.