ArticleChinese medical journal2019
Clinical significance and influencing factors of linked color imaging technique in real-time diagnosis of active Helicobacter pylori infection.
Article in Chinese medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- The Diagnostic Performance of Linked Color Imaging Compared to White Light Imaging in Endoscopic Diagnosis ofGut and liver · 2024Pooled it
- Novel endoscopic techniques for the diagnosis of gastricFrontiers in microbiology · 2024Pooled it
- Vitamins andFrontiers in nutrition · 2021Pooled it
- Review
- Endoscopic appearances of gastric mucosa in different endoscopic models according to H. pylori infection status.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Simultaneous detection of Helicobacter pylori infection comparing between white light and image-enhanced endoscopy.BMC gastroenterology · 2024Article
- Clinical usefulness of linked color imaging in identifyingWorld journal of gastrointestinal endoscopy · 2023Article
- The Agreement between Endoscopic and Histopathological Findings of Esophageal and Gastroduodenal Lesions and Its Relationship with Endoscopists' Experience.Middle East journal of digestive diseases · 2023Article
- Linked Color Imaging for Stomach.Diagnostics (Basel, Switzerland) · 2023Review
- An explainable artificial intelligence system for diagnosingTherapeutic advances in gastroenterology · 2023Article
- Diagnosis ofDiagnostics (Basel, Switzerland) · 2021Review
- What Is New inJournal of clinical medicine · 2021Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDetermining the Helicobacter pylori (H. pylori) infection state during the gastroscopic process is important but still challenging. The linked color imaging (LCI) technique might emphasize the mucosal color change after H. pylori infection, which might help the diagnosis. In the present study, we aimed to compare the LCI technique with traditional white light imaging (WLI) endoscopy for diagnosing active H. pylori infection.
methodsWe collected and analyzed gastroscopic images from 103 patients in our hospital from November 2017 to March 2018, including both LCI and WLI modes. All images were randomly disordered and independently evaluated by four endoscopists who were blinded to the H. pylori status of patients. In addition, the H. pylori state was determined by both rapid urease test and pathology staining. The sensitivity, specificity, positive prediction value (PPV), and negative prediction value (NPV) were calculated for the detection of H. pylori infection. Moreover, the kappa value and interclass correlation coefficient (ICC) were used to evaluate the inter-observer variety by SPSS 24.0 software.
resultsOf the 103 enrolled patients, 27 of them were positive for H. pylori infection, while the 76 patients were negative. In total, 388 endoscopic images were selected, including 197 WLI and 191 LCI. The accuracy rate for H. pylori evaluation in the corpus LCI group was significantly higher than other groups (81.2% vs. 64.3%-76.5%, χ = 34.852, P < 0.001). Moreover, the corpus LCI group had the optimal diagnostic power with the sensitivity of 85.41% (95% confidence interval [CI]: 76.40%-91.51%), the specificity of 79.71% (95% CI: 74.38%-84.19%), the PPV of 59.42% (95% CI: 50.72%-67.59%), and the NPV of 94.02% (95% CI: 89.95%-96.56%), respectively. The kappa values between different endoscopists were higher with LCI than with WLI (0.433-0.554 vs. 0.331-0.554). Consistently, the ICC value was also higher with LCI than with WLI (0.501 [95% CI: 0.429-0.574] vs. 0.397 [95% CI: 0.323-0.474]). We further analyzed the factors that might lead to misjudgment, revealing that active inflammation might disturb WLI judgment (accuracy rate: 58.70% vs. 76.16%, χ = 21.373, P < 0.001). Atrophy and intestinal metaplasia might affect the accuracy of the LCI results (accuracy rate: 66.96% vs. 73.47%, χ = 2.027; 68.42% vs. 73.53%, χ = 1.594, respectively); however, without statistical significance (P = 0.154 and 0.207, respectively).
conclusionsThe application of LCI at the corpus to identify H. pylori infection is reliable and superior to WLI. The inter-observer variability is lower with LCI than with WLI.
trial registrationChinese Clinical Trial Registry: ChiCTR1800016730; http://www.chictr.org.cn/showproj.aspx?proj=28400.
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