Evidence map›Paper›PMID 31651369›Full record

ReviewMilitary Medical Research2019

Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing.

Jing-Jing Ji, Jie Fan

Open access · diamondAbstract readReview
In one paragraph

Review in Military Medical Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. From COPD to Lung Cancer: Mechanisms Linking, Diagnosis, Treatment, and Prognosis.International journal of chronic obstructive pulmonary disease · 2022
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Overexpression of NNT-AS1 Activates TGF-BioMed research international · 2020
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Jing-Jing JiDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Jie FanDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. jif7@pitt.edu.ORCID 0000-0002-0090-2704
University of Pittsburgh · US

Funding

IMPROVEMENT OF ORGAN FUNCTION AFTER SEVERE HYPOVOLEMIAR01HL076179 · NHLBI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PING WANG · 2004 to 2026
$7.6M
Cell Priming, Receptor Cross-Talk, and Acute Lung InjuryR01HL079669 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAN, JIE, WILSON, MARK A. · 2005 to 2019
$4.0M
Macrophage Pyroptosis Mechanism of Post-Trauma Acute Lung InjuryR01HL139547 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAN, JIE · 2018 to 2021
$1.6M
Cell Death Mechanism of Acute Lung Injury in SepsisI01BX002729 · VA · VETERANS HEALTH ADMINISTRATION · PI FAN, JIE · 2015 to 2020
–
BLR&D Research Career Scientist Award ApplicationIK6BX004211 · VA · VETERANS HEALTH ADMINISTRATION · PI FAN, JIE · 2018 to 2022
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BLRD VA I01 BX002729BLRD VA IK6 BX004211NHLBI NIH HHS R01 HL076179NHLBI NIH HHS R01 HL079669NHLBI NIH HHS R01 HL139547
6 · The paper itself

Abstract

The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial cells and leukocytes. Myeloid cells of the innate immune system and epithelial cells form a critical barrier in the lung. Recently developed unbiased next generation sequencing (NGS) has revealed cell heterogeneity in the lung with respect to physiology and pathology and has reshaped our knowledge. New phenotypes and distinct gene signatures have been identified, and these new findings enhance the diagnosis and treatment of lung diseases. Here, we present a review of the new NGS findings on myeloid cells in lung development, homeostasis, and lung diseases, including acute lung injury (ALI), lung fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer.

Indexed as

High-Throughput Nucleotide SequencingEpithelial CellsHomeostasisHumansLungLung DiseasesMyeloid CellsSequence Analysis, DNASequence Analysis, RNAAcute lung injuryLung cancerLung developmentLung diseaseSingle-cell RNA sequencing

Identifiers

PMID31651369
PMCPMC6814050
OpenAlexW2981463992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.