Evidence map›Paper›PMID 31651355›Full record

ArticleTrials2019

Sahaj Samadhi meditation vs a Health Enhancement Program in improving late-life depression severity and executive function: study protocol for a two-site, randomized controlled trial.

Stephen Benjamin Peckham, Emily Ionson, Marouane Nassim, Kevin Ojha, Lena Palaniyappan, Joe Gati, Jean Thebérge, Andrea Lazosky, Mark Speechley, Imants Barušs and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03564041 (Alternative Treatments to Help Late-Life Depression Study Protocol), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03564041 naterminatednot on this map

Alternative Treatments to Help Late-Life Depression Study Protocol

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2018 to 2022Enrolled95ConditionsLate-life Depression, Treatment-resistant DepressionArmsSahaj Samadhi Meditation (SSM), Health Enhancement Program (HEP)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Stephen Benjamin PeckhamGeriatric Mood Disorders Laboratory, Lawson Health Research Institute, London Health Sciences Centre, London, ON, Canada.
Emily IonsonGeriatric Mood Disorders Laboratory, Lawson Health Research Institute, London Health Sciences Centre, London, ON, Canada.
Marouane NassimMcGill Meditation and Mind-Body Medicine Research Clinic (MMMM-RC), Jewish General Hospital, Montréal, QC, Canada.
Kevin OjhaWestern University, London, ON, Canada.
Lena PalaniyappanDepartment of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Joe GatiRobarts Research Institute, Western University, London, ON, Canada.
Jean ThebérgeDepartment of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Andrea LazoskyLondon Health Sciences Centre, #A2-607, Victoria Hospital, LHSC, 800 Commissioners Road East, N6A 5W9, London, ON, Canada.
Mark SpeechleyDepartment of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Imants BarušsDepartment of Psychology, King's University College, Western University, London, ON, Canada.
Soham RejMcGill Meditation and Mind-Body Medicine Research Clinic (MMMM-RC), Jewish General Hospital, Montréal, QC, Canada.
Akshya VasudevGeriatric Mood Disorders Laboratory, Lawson Health Research Institute, London Health Sciences Centre, London, ON, Canada. akshya.vasudev@lhsc.on.ca.ORCID http://orcid.org/0000-0002-0423-4598
Western University · CAJewish General Hospital · CALawson Health Research Institute · CALondon Health Sciences Centre · CA

Funding

CIHR 389099
6 · The paper itself

Abstract

backgroundRecent estimates suggest an 11% prevalence of current late-life depression (LLD) and a lifetime prevalence of 16-20%. LLD leads to cognitive disturbance as well as a nearly two to three times increased risk of dementia. We conducted a recent randomized controlled trial (RCT) which demonstrated that Sahaj Samadhi meditation (SSM), an easy-to-implement, meditation-based augmentation strategy, led to higher rates of symptom remission when compared to treatment as usual (40.0 vs 16.3%; odds ratio, 3.36; 95% CI 1.06-10.64; p = 0.040). Here we present a protocol describing a two-site, blinded, RCT, comparing an SSM arm to an active-control arm - a Health Enhancement Program (HEP) intervention - in their ability to reduce depressive symptoms and improve executive functioning, among several other exploratory outcomes. METHODS/

designOne hundred and ninety-two (n = 192) participants with LLD will be recruited at two sites (London, ON, Canada, and Montreal, QC, Canada). Participants will undergo stratified randomization with regards to site and the presence of treatment-resistant-LLD (TR-LLD) or not, to either SSM or HEP. We will assess change in (1) depression severity using the Hamilton Depression Rating Scale (HAM-D), (2) executive functioning, and (3) other exploratory physiological and mood-based measures, at baseline (0 weeks), post intervention (12 weeks), and 26 weeks after baseline. Raters, clinicians, and care providers will be blinded to group allocation while participants will be blinded to the study hypotheses. DISCUSSION: This study should more definitively assess whether SSM can be used as an augmentation strategy in routine clinical care for patients suffering from LLD and TR-LLD. If the effects of SSM are significantly better than HEP, it will offer support for the routine use of this intervention to manage LLD/TR-LLD and comorbid declines in executive dysfunction. The results of this study could also inform whether SSM can improve/prevent cognitive decline in LLD.

trial registrationClinicalTrials.gov, ID: NCT03564041 . Registered on 20 June 2018.

Indexed as

AffectExecutive FunctionMeditationAgedAged, 80 and overAge FactorsDepressionFemaleHumansMaleMiddle AgedMulticenter Studies as TopicOntarioQuebecRandomized Controlled Trials as TopicSeverity of Illness IndexExecutive functioningHealth Enhancement ProgramLate-life depressionRandomized controlled trialSahaj Samadhi meditationTreatment-resistant late-life depression

Identifiers

PMID31651355
PMCPMC6814044
OpenAlexW2981930791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.